Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China
Background: The impact of coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) on long-term health-related quality of life (HRQOL) in children has not been well documented. Methods: This study investigated long-term HRQOL in a large sample of children diagnosed with KD-related CAAs. A ca...
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The Texas Heart Institute
2025-02-01
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| Series: | Texas Heart Institute Journal |
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| Online Access: | https://thij.kglmeridian.com/view/journals/thij/52/1/article-e248393.xml |
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| author | Yun Zhou, MD Mei Chen, MD Wenting Gao, MD Yu Chen, MD Ying Meng, MD |
| author_facet | Yun Zhou, MD Mei Chen, MD Wenting Gao, MD Yu Chen, MD Ying Meng, MD |
| author_sort | Yun Zhou, MD |
| collection | DOAJ |
| description | Background:
The impact of coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) on long-term health-related quality of life (HRQOL) in children has not been well documented.
Methods:
This study investigated long-term HRQOL in a large sample of children diagnosed with KD-related CAAs. A case-control, retrospective study included 66 patients with KD-related CAAs. A total of 98 hospitalized patients were matched as controls based on age and sex: 49 patients were allocated to a group with pneumonia and 49 patients were allocated to a group with arterio-arterial fistula. Both child-reported and parent-proxy–reported Pediatric Quality of Life Inventory surveys were collected.
Results:
The median (IQR) follow-up period was 5.64 (3.81-7.47) years (range, 1.03-10.67 years). The mean (SD) age at diagnosis was 3.73 (1.93) years. At baseline, children and parents as their proxies reported similar HRQOL scores for KD-related CAAs and arterio-arterial fistula that were considerably lower than for pneumonia, respectively. At long-term follow-up, children in the small and medium-sized aneurysms group reported a mean (SD) score of 81.61 (19.50), which was comparable to the arterio-arterial fistula group (83.32 [18.24]), 9.51 points lower than that of the pneumonia group (P = .014), and 9.70 points higher than that of the giant aneurysms group (P = .012). Parents also reported a comparable mean (SD) score of 81.03 (12.57) vs 83.30 (15.17) in the small and medium-sized aneurysms group and arterio-arterial fistula group, both of which had statistically significantly lower scores than the pneumonia group (P = .010) and higher scores than the giant aneurysms group (P = .009).
Conclusion:
Despite improvement in HRQOL scores, children with documented KD-related CAAs without complete recovery often encountered issues that disrupted their well-being during long-term follow-up. Routine outpatient HRQOL screening could be instituted to help eliminate the risk of long-term disability following initial clinical improvement. |
| format | Article |
| id | doaj-art-430cfd12f9ba40aa9a8fb5bf04dd4943 |
| institution | Kabale University |
| issn | 1526-6702 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Texas Heart Institute |
| record_format | Article |
| series | Texas Heart Institute Journal |
| spelling | doaj-art-430cfd12f9ba40aa9a8fb5bf04dd49432025-02-05T09:21:52ZengThe Texas Heart InstituteTexas Heart Institute Journal1526-67022025-02-0152111210.14503/THIJ-24-8393i1526-6702-52-1-e248393Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, ChinaYun Zhou, MDMei Chen, MDWenting Gao, MDYu Chen, MDYing Meng, MDBackground: The impact of coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) on long-term health-related quality of life (HRQOL) in children has not been well documented. Methods: This study investigated long-term HRQOL in a large sample of children diagnosed with KD-related CAAs. A case-control, retrospective study included 66 patients with KD-related CAAs. A total of 98 hospitalized patients were matched as controls based on age and sex: 49 patients were allocated to a group with pneumonia and 49 patients were allocated to a group with arterio-arterial fistula. Both child-reported and parent-proxy–reported Pediatric Quality of Life Inventory surveys were collected. Results: The median (IQR) follow-up period was 5.64 (3.81-7.47) years (range, 1.03-10.67 years). The mean (SD) age at diagnosis was 3.73 (1.93) years. At baseline, children and parents as their proxies reported similar HRQOL scores for KD-related CAAs and arterio-arterial fistula that were considerably lower than for pneumonia, respectively. At long-term follow-up, children in the small and medium-sized aneurysms group reported a mean (SD) score of 81.61 (19.50), which was comparable to the arterio-arterial fistula group (83.32 [18.24]), 9.51 points lower than that of the pneumonia group (P = .014), and 9.70 points higher than that of the giant aneurysms group (P = .012). Parents also reported a comparable mean (SD) score of 81.03 (12.57) vs 83.30 (15.17) in the small and medium-sized aneurysms group and arterio-arterial fistula group, both of which had statistically significantly lower scores than the pneumonia group (P = .010) and higher scores than the giant aneurysms group (P = .009). Conclusion: Despite improvement in HRQOL scores, children with documented KD-related CAAs without complete recovery often encountered issues that disrupted their well-being during long-term follow-up. Routine outpatient HRQOL screening could be instituted to help eliminate the risk of long-term disability following initial clinical improvement.https://thij.kglmeridian.com/view/journals/thij/52/1/article-e248393.xmlmucocutaneous lymph node syndromecoronary aneurysmsarterio-arterial fistulaquality of life |
| spellingShingle | Yun Zhou, MD Mei Chen, MD Wenting Gao, MD Yu Chen, MD Ying Meng, MD Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China Texas Heart Institute Journal mucocutaneous lymph node syndrome coronary aneurysms arterio-arterial fistula quality of life |
| title | Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China |
| title_full | Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China |
| title_fullStr | Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China |
| title_full_unstemmed | Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China |
| title_short | Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China |
| title_sort | long term health related quality of life in kawasaki disease related coronary artery aneurysm a large single center assessment in nanjing china |
| topic | mucocutaneous lymph node syndrome coronary aneurysms arterio-arterial fistula quality of life |
| url | https://thij.kglmeridian.com/view/journals/thij/52/1/article-e248393.xml |
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