5-HT1A receptor: its role in the regulation of different kinds of behavior
Brain serotonin (5-HT) is known to be involved in the control of a wide range of physiological functions as well as of different kinds of behavior. Such polyfunctionality of 5-HT is mediated by numerous 5-HT receptors. Currently, 14 different 5-HT receptor subtypes expressed in the mammals have been...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2016-05-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/584 |
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| author | V. S. Naumenko E. G. Ponimaskin N. K. Popova |
| author_facet | V. S. Naumenko E. G. Ponimaskin N. K. Popova |
| author_sort | V. S. Naumenko |
| collection | DOAJ |
| description | Brain serotonin (5-HT) is known to be involved in the control of a wide range of physiological functions as well as of different kinds of behavior. Such polyfunctionality of 5-HT is mediated by numerous 5-HT receptors. Currently, 14 different 5-HT receptor subtypes expressed in the mammals have been identified. The 5-HT1А receptor is one of the most extensively characterised members of the serotonin receptor family. Increased interest to the 5-HT1А receptor is based on (1) a key role in the autoregulation of the brain serotonergic system due to the postsynaptic and presynaptic localization, (2) a great body of data demonstrating implication of 5-HT1А receptor in the control of various physiological functions (3) involvement of 5-HT1А receptors in the mechanisms of depression, anxiety and suicide. The review describes literature and original data on factors affecting the expression and functional activity of 5-HT1А receptors and the involvement of 5-HT1А receptors in the regulation of normal and pathological behavior. The structure of the 5-HT1А receptor gene is described and new data on the posttranslational regulation of 5-HT1А receptor functional activity are provided. A special focus was given to the interaction between 5-HT1А and 5-HT7 receptors followed by heterodimer formation and the role of heterodimerization in the functional inactivation of the 5-HT1А receptor. The implication of 5-HT1А receptors in the regulation of aggressive behavior, catalepsy, anxiety, depression and hibernation was shown. Special attention is focused on the involvement of 5-HT1А receptors in the regulation of 1) fear-induced aggression towards man – the basis of domestication, 2) intermale aggression underling asocial behavior in men, 3) depression and in the mechanism of antidepressant action. The described data extend the idea on the 5-HT1А receptor as a key player in the brain 5-HT system. |
| format | Article |
| id | doaj-art-4309dea7e2464298bed81d9de43be1f8 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-4309dea7e2464298bed81d9de43be1f82025-02-01T09:58:02ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592016-05-0120218019010.18699/VJ16.1354635-HT1A receptor: its role in the regulation of different kinds of behaviorV. S. Naumenko0E. G. Ponimaskin1N. K. Popova2Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cellular Neurophysiology, Hannover Medical High School, Hannover, GermanyInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaBrain serotonin (5-HT) is known to be involved in the control of a wide range of physiological functions as well as of different kinds of behavior. Such polyfunctionality of 5-HT is mediated by numerous 5-HT receptors. Currently, 14 different 5-HT receptor subtypes expressed in the mammals have been identified. The 5-HT1А receptor is one of the most extensively characterised members of the serotonin receptor family. Increased interest to the 5-HT1А receptor is based on (1) a key role in the autoregulation of the brain serotonergic system due to the postsynaptic and presynaptic localization, (2) a great body of data demonstrating implication of 5-HT1А receptor in the control of various physiological functions (3) involvement of 5-HT1А receptors in the mechanisms of depression, anxiety and suicide. The review describes literature and original data on factors affecting the expression and functional activity of 5-HT1А receptors and the involvement of 5-HT1А receptors in the regulation of normal and pathological behavior. The structure of the 5-HT1А receptor gene is described and new data on the posttranslational regulation of 5-HT1А receptor functional activity are provided. A special focus was given to the interaction between 5-HT1А and 5-HT7 receptors followed by heterodimer formation and the role of heterodimerization in the functional inactivation of the 5-HT1А receptor. The implication of 5-HT1А receptors in the regulation of aggressive behavior, catalepsy, anxiety, depression and hibernation was shown. Special attention is focused on the involvement of 5-HT1А receptors in the regulation of 1) fear-induced aggression towards man – the basis of domestication, 2) intermale aggression underling asocial behavior in men, 3) depression and in the mechanism of antidepressant action. The described data extend the idea on the 5-HT1А receptor as a key player in the brain 5-HT system.https://vavilov.elpub.ru/jour/article/view/584serotonin5-ht1а receptor5-ht7 receptorserotonin receptors interactionanxietydepressive behavioraggressive behaviorcatalepsyhibernation |
| spellingShingle | V. S. Naumenko E. G. Ponimaskin N. K. Popova 5-HT1A receptor: its role in the regulation of different kinds of behavior Вавиловский журнал генетики и селекции serotonin 5-ht1а receptor 5-ht7 receptor serotonin receptors interaction anxiety depressive behavior aggressive behavior catalepsy hibernation |
| title | 5-HT1A receptor: its role in the regulation of different kinds of behavior |
| title_full | 5-HT1A receptor: its role in the regulation of different kinds of behavior |
| title_fullStr | 5-HT1A receptor: its role in the regulation of different kinds of behavior |
| title_full_unstemmed | 5-HT1A receptor: its role in the regulation of different kinds of behavior |
| title_short | 5-HT1A receptor: its role in the regulation of different kinds of behavior |
| title_sort | 5 ht1a receptor its role in the regulation of different kinds of behavior |
| topic | serotonin 5-ht1а receptor 5-ht7 receptor serotonin receptors interaction anxiety depressive behavior aggressive behavior catalepsy hibernation |
| url | https://vavilov.elpub.ru/jour/article/view/584 |
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