Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China
The global epidemic of bovine coronavirus (BCoV) has caused enormous economic losses. The characterisation and genetic composition of endemic strains in Southwest China remain elusive. This study aimed to fill this gap by isolating three BCoV strains from this region and sequencing their whole genom...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2306-7381/12/1/9 |
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| author | Qingqing Li Huili Bai Yan Pan Yuying Liao Zhe Pei Cuilan Wu Chunxia Ma Zhongwei Chen Changting Li Yu Gong Jing Liu Yangyan Yin Ling Teng Leping Wang Ezhen Zhang Tianchao Wei Hao Peng |
| author_facet | Qingqing Li Huili Bai Yan Pan Yuying Liao Zhe Pei Cuilan Wu Chunxia Ma Zhongwei Chen Changting Li Yu Gong Jing Liu Yangyan Yin Ling Teng Leping Wang Ezhen Zhang Tianchao Wei Hao Peng |
| author_sort | Qingqing Li |
| collection | DOAJ |
| description | The global epidemic of bovine coronavirus (BCoV) has caused enormous economic losses. The characterisation and genetic composition of endemic strains in Southwest China remain elusive. This study aimed to fill this gap by isolating three BCoV strains from this region and sequencing their whole genomes. To elucidate the genetic evolution and characterisation of the prevalent strains, the results of BCoV sequences were compared in GenBank, with a focus on genetic evolution, mutation, and recombination patterns. The results showed close homology between strains NN190313 and NN230328, while strain NN221214 showed less similarity to these two strains but clustered with the French strain of the European branch. Intriguingly, NN190313 and NN230328 were grouped with goat-derived BCoV strains from Jiangsu Province in Eastern China in the Asian–American branch. In addition, recombination analyses revealed significant signals between NN230328 and either a Chinese goat-derived strain (XJCJ2301G) or a Shandong strain (ShX310). This study highlights the importance of monitoring cross-species transmission between cattle and goats, especially in the mountainous areas of Southwest China where mixed farming occurs, and thus, the monitoring of cross-species transmission between cattle and goats is important for preventing new public health challenges, providing important insights for research on cross-species transmission, early prevention, and control measures, with potential applications in vaccine development. |
| format | Article |
| id | doaj-art-42ee1577ca3a4f088f355dc31bbc62d5 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-42ee1577ca3a4f088f355dc31bbc62d52025-01-24T13:51:58ZengMDPI AGVeterinary Sciences2306-73812024-12-01121910.3390/vetsci12010009Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest ChinaQingqing Li0Huili Bai1Yan Pan2Yuying Liao3Zhe Pei4Cuilan Wu5Chunxia Ma6Zhongwei Chen7Changting Li8Yu Gong9Jing Liu10Yangyan Yin11Ling Teng12Leping Wang13Ezhen Zhang14Tianchao Wei15Hao Peng16College of Animal Science and Technology, Guangxi University, Nanning 530004, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning 530004, ChinaCollege of Animal Science and Technology, Guangxi Agricultural Vocational and Technical University, Nanning 530007, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaSchool of Neuroscience, The City College of New York, New York, NY 10031, USACollege of Animal Science and Technology, Guangxi University, Nanning 530004, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning 530004, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaGuizhou Animal Husbandry and Veterinary Research Institute, Guiyang 550005, ChinaGuizhou Animal Husbandry and Veterinary Research Institute, Guiyang 550005, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaInstitute of Agricultural Products Processing, Guangxi Academy of Agricultural Sciences, Nanning 530007, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning 530004, ChinaGuangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, ChinaThe global epidemic of bovine coronavirus (BCoV) has caused enormous economic losses. The characterisation and genetic composition of endemic strains in Southwest China remain elusive. This study aimed to fill this gap by isolating three BCoV strains from this region and sequencing their whole genomes. To elucidate the genetic evolution and characterisation of the prevalent strains, the results of BCoV sequences were compared in GenBank, with a focus on genetic evolution, mutation, and recombination patterns. The results showed close homology between strains NN190313 and NN230328, while strain NN221214 showed less similarity to these two strains but clustered with the French strain of the European branch. Intriguingly, NN190313 and NN230328 were grouped with goat-derived BCoV strains from Jiangsu Province in Eastern China in the Asian–American branch. In addition, recombination analyses revealed significant signals between NN230328 and either a Chinese goat-derived strain (XJCJ2301G) or a Shandong strain (ShX310). This study highlights the importance of monitoring cross-species transmission between cattle and goats, especially in the mountainous areas of Southwest China where mixed farming occurs, and thus, the monitoring of cross-species transmission between cattle and goats is important for preventing new public health challenges, providing important insights for research on cross-species transmission, early prevention, and control measures, with potential applications in vaccine development.https://www.mdpi.com/2306-7381/12/1/9bovine coronaviruswhole-genome sequencingcross-species transmissiongenetic evolution analysis |
| spellingShingle | Qingqing Li Huili Bai Yan Pan Yuying Liao Zhe Pei Cuilan Wu Chunxia Ma Zhongwei Chen Changting Li Yu Gong Jing Liu Yangyan Yin Ling Teng Leping Wang Ezhen Zhang Tianchao Wei Hao Peng Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China Veterinary Sciences bovine coronavirus whole-genome sequencing cross-species transmission genetic evolution analysis |
| title | Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China |
| title_full | Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China |
| title_fullStr | Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China |
| title_full_unstemmed | Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China |
| title_short | Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China |
| title_sort | genome wide genomic analysis and evolutionary insights into bovine coronavirus strains in southwest china |
| topic | bovine coronavirus whole-genome sequencing cross-species transmission genetic evolution analysis |
| url | https://www.mdpi.com/2306-7381/12/1/9 |
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