The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy
Colorectal cancer (CRC) is a common cancer with high mortality rates. Despite progress in treatment, it remains an incurable disease for many patients. In CRC, the tumor microenvironment (TME) plays critical roles in tumor growth, progression, patients’ prognosis, and response to treatments. Underst...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325000385 |
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| author | Abdo Meyiah Faez Iqbal Khan Dia Aldeen Alfaki Khaled Murshed Afsheen Raza Eyad Elkord |
| author_facet | Abdo Meyiah Faez Iqbal Khan Dia Aldeen Alfaki Khaled Murshed Afsheen Raza Eyad Elkord |
| author_sort | Abdo Meyiah |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common cancer with high mortality rates. Despite progress in treatment, it remains an incurable disease for many patients. In CRC, the tumor microenvironment (TME) plays critical roles in tumor growth, progression, patients’ prognosis, and response to treatments. Understanding TME complexities is important for developing effective therapies. In vitro and in vivo preclinical models are critical in understanding the disease, discovering potential targets, and developing effective therapeutics. In this review, we focus on preclinical research studies associated with modulation of the TME in CRC. These models give insights into understanding the role of stroma and immune cell components of the TME in CRC and improve clinical responses, providing insights in novel treatment options. Various studies have focused on targeting the TME in CRC to improve responses to different therapeutic approaches. These include identifying targets for cancer therapies, targeting molecular signaling, and enhancing the efficacy of immunotherapeutic modalities. Furthermore, targeting stromal and angiogenic factors in the TME may provide new therapeutic options. Overall, understanding and targeting the TME in CRC is a promising approach for improving therapeutic outcomes. |
| format | Article |
| id | doaj-art-42dba72eef854b4986913a369e530d2b |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-42dba72eef854b4986913a369e530d2b2025-02-04T04:10:22ZengElsevierTranslational Oncology1936-52332025-03-0153102307The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapyAbdo Meyiah0Faez Iqbal Khan1Dia Aldeen Alfaki2Khaled Murshed3Afsheen Raza4Eyad Elkord5Department of Biosciences and Bioinformatics & Suzhou Municipal Key Lab of Biomedical Sciences and Translational Immunology, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, ChinaDepartment of Biosciences and Bioinformatics & Suzhou Municipal Key Lab of Biomedical Sciences and Translational Immunology, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, ChinaDepartment of Haematology, Al-Zaeim Al-Azhari University, Khartoum, SudanDepartment of Pathology, Hamad Medical Corporation, Doha, QatarCollege of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab EmiratesDepartment of Biosciences and Bioinformatics & Suzhou Municipal Key Lab of Biomedical Sciences and Translational Immunology, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China; College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates; Biomedical Research Center, School of Science, Engineering and Environment, University of Salford, Manchester, UK; Corresponding author at: Department of Biosciences and Bioinformatics & Suzhou Municipal Key Lab of Biomedical Sciences and Translational Immunology, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.Colorectal cancer (CRC) is a common cancer with high mortality rates. Despite progress in treatment, it remains an incurable disease for many patients. In CRC, the tumor microenvironment (TME) plays critical roles in tumor growth, progression, patients’ prognosis, and response to treatments. Understanding TME complexities is important for developing effective therapies. In vitro and in vivo preclinical models are critical in understanding the disease, discovering potential targets, and developing effective therapeutics. In this review, we focus on preclinical research studies associated with modulation of the TME in CRC. These models give insights into understanding the role of stroma and immune cell components of the TME in CRC and improve clinical responses, providing insights in novel treatment options. Various studies have focused on targeting the TME in CRC to improve responses to different therapeutic approaches. These include identifying targets for cancer therapies, targeting molecular signaling, and enhancing the efficacy of immunotherapeutic modalities. Furthermore, targeting stromal and angiogenic factors in the TME may provide new therapeutic options. Overall, understanding and targeting the TME in CRC is a promising approach for improving therapeutic outcomes.http://www.sciencedirect.com/science/article/pii/S1936523325000385CRCTumor microenvironmentCancer therapyPreclinical models |
| spellingShingle | Abdo Meyiah Faez Iqbal Khan Dia Aldeen Alfaki Khaled Murshed Afsheen Raza Eyad Elkord The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy Translational Oncology CRC Tumor microenvironment Cancer therapy Preclinical models |
| title | The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy |
| title_full | The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy |
| title_fullStr | The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy |
| title_full_unstemmed | The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy |
| title_short | The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy |
| title_sort | colorectal cancer microenvironment preclinical progress in identifying targets for cancer therapy |
| topic | CRC Tumor microenvironment Cancer therapy Preclinical models |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325000385 |
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