Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure

Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure

Sepsis is a systemic condition caused by a dysregulated host response to infection and often associated with excessive release of proinflammatory cytokines resulting in multi-organ failure (MOF), including cardiac dysfunction. Despite a number of effective supportive treatments (e.g. ventilation, di...

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Bibliographic Details
Main Authors: Chiara Verra, Maria Kerstin Paulmann, Jamila Wegener, Enrica Marzani, Gustavo Ferreira Alves, Massimo Collino, Sina Maren Coldewey, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
sepsis
SYK
cardiac dysfunction
MOF
cytokine storm
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1447901/full
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