Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer
Sawsan Sudqi Said, Wisam Nabeel Ibrahim Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarCorrespondence: Wisam Nabeel Ibrahim, Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Qatar, Email w.ibrahim@qu.e...
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Dove Medical Press
2025-01-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/gut-microbiotatumor-microenvironment-interactions-mechanisms-and-clini-peer-reviewed-fulltext-article-CMAR |
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| author | Said SS Ibrahim WN |
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| description | Sawsan Sudqi Said, Wisam Nabeel Ibrahim Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarCorrespondence: Wisam Nabeel Ibrahim, Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Qatar, Email w.ibrahim@qu.edu.qaAbstract: Cancer immunotherapy has transformed cancer treatment in recent years, with immune checkpoint inhibitors (ICIs) emerging as a key therapeutic approach. ICIs work by inhibiting the mechanisms that allow tumors to evade immune detection. Although ICIs have shown promising results, especially in solid tumors, patient responses vary widely due to multiple intrinsic and extrinsic factors within the tumor microenvironment. Emerging evidence suggests that the gut microbiota plays a pivotal role in modulating immune responses at the tumor site and may even influence treatment outcomes in cancer patients receiving ICIs. This review explores the complex interactions between the gut microbiota and the tumor microenvironment, examining how these interactions could impact the effectiveness of ICI therapy. Furthermore, we discuss how dysbiosis, an imbalance in gut microbiota composition, may contribute to resistance to ICIs, and highlight microbiota-targeted strategies to potentially overcome this challenge. Additionally, we review recent studies investigating the diagnostic potential of microbiota profiles in cancer patients, considering how microbial markers might aid in early detection and stratification of patient responses to ICIs. By integrating insights from recent preclinical and clinical studies, we aim to shed light on the potential of microbiome modulation as an adjunct to cancer immunotherapy and as a diagnostic tool, paving the way for personalized therapeutic approaches that optimize patient outcomes.Keywords: ICIs, immunotherapy, gut microbiota, microbiome, tumor microenvironment |
| format | Article |
| id | doaj-art-42b9e640b96449f19b87b93ea5314922 |
| institution | Kabale University |
| issn | 1179-1322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Cancer Management and Research |
| spelling | doaj-art-42b9e640b96449f19b87b93ea53149222025-01-27T18:05:33ZengDove Medical PressCancer Management and Research1179-13222025-01-01Volume 1717119299618Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in CancerSaid SSIbrahim WNSawsan Sudqi Said, Wisam Nabeel Ibrahim Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarCorrespondence: Wisam Nabeel Ibrahim, Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Qatar, Email w.ibrahim@qu.edu.qaAbstract: Cancer immunotherapy has transformed cancer treatment in recent years, with immune checkpoint inhibitors (ICIs) emerging as a key therapeutic approach. ICIs work by inhibiting the mechanisms that allow tumors to evade immune detection. Although ICIs have shown promising results, especially in solid tumors, patient responses vary widely due to multiple intrinsic and extrinsic factors within the tumor microenvironment. Emerging evidence suggests that the gut microbiota plays a pivotal role in modulating immune responses at the tumor site and may even influence treatment outcomes in cancer patients receiving ICIs. This review explores the complex interactions between the gut microbiota and the tumor microenvironment, examining how these interactions could impact the effectiveness of ICI therapy. Furthermore, we discuss how dysbiosis, an imbalance in gut microbiota composition, may contribute to resistance to ICIs, and highlight microbiota-targeted strategies to potentially overcome this challenge. Additionally, we review recent studies investigating the diagnostic potential of microbiota profiles in cancer patients, considering how microbial markers might aid in early detection and stratification of patient responses to ICIs. By integrating insights from recent preclinical and clinical studies, we aim to shed light on the potential of microbiome modulation as an adjunct to cancer immunotherapy and as a diagnostic tool, paving the way for personalized therapeutic approaches that optimize patient outcomes.Keywords: ICIs, immunotherapy, gut microbiota, microbiome, tumor microenvironmenthttps://www.dovepress.com/gut-microbiotatumor-microenvironment-interactions-mechanisms-and-clini-peer-reviewed-fulltext-article-CMARicisimmunotherapygut microbiotamicrobiometumor microenvironment |
| spellingShingle | Said SS Ibrahim WN Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer Cancer Management and Research icis immunotherapy gut microbiota microbiome tumor microenvironment |
| title | Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer |
| title_full | Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer |
| title_fullStr | Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer |
| title_full_unstemmed | Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer |
| title_short | Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer |
| title_sort | gut microbiota ndash tumor microenvironment interactions mechanisms and clinical implications for immune checkpoint inhibitor efficacy in cancer |
| topic | icis immunotherapy gut microbiota microbiome tumor microenvironment |
| url | https://www.dovepress.com/gut-microbiotatumor-microenvironment-interactions-mechanisms-and-clini-peer-reviewed-fulltext-article-CMAR |
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