Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?
Dual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor represents the cornerstone therapy for patients with acute coronary syndromes or undergoing percutaneous interventions, leading to a reduction of subsequent ischemic events. Variable response to clopidogrel has received close atte...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/195456 |
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| author | Adriana Dana Oprea Wanda M. Popescu |
| author_facet | Adriana Dana Oprea Wanda M. Popescu |
| author_sort | Adriana Dana Oprea |
| collection | DOAJ |
| description | Dual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor represents the cornerstone therapy for patients with acute coronary syndromes or undergoing percutaneous interventions, leading to a reduction of subsequent ischemic events. Variable response to clopidogrel has received close attention, and pharmacokinetic, pharmacodynamic, and pharmacogenomic factors have been identified as culprits. This led to the introduction of newer, potentially safer, and more effective antiplatelet agents (prasugrel and ticagrelor). Additionally, several point-of-care assays of platelet function have been developed in recent years to rapidly screen individuals on antiplatelet therapy. While the routine use of platelet function testing is uncertain and not currently recommended, it may be useful in instances when the degree of platelet inhibition may be uncertain such as high-risk patients undergoing percutaneous coronary intervention or when there may be a suspected pharmacodynamic interaction with other drugs. The current paper focuses on the P2Y12 receptor inhibitors and their pharmacogenetics and indications in patients with acute coronary syndromes or receiving percutaneous coronary interventions as well as the applicability of platelet function testing in this clinical context. |
| format | Article |
| id | doaj-art-42b219a6bdbd4bfda11abf248f7d0490 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-42b219a6bdbd4bfda11abf248f7d04902025-02-03T05:58:41ZengWileyCardiology Research and Practice2090-80162090-05972013-01-01201310.1155/2013/195456195456Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?Adriana Dana Oprea0Wanda M. Popescu1Department of Anesthesiology, Yale University, New Haven, CT 06520, USADepartment of Anesthesiology, Yale University, New Haven, CT 06520, USADual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor represents the cornerstone therapy for patients with acute coronary syndromes or undergoing percutaneous interventions, leading to a reduction of subsequent ischemic events. Variable response to clopidogrel has received close attention, and pharmacokinetic, pharmacodynamic, and pharmacogenomic factors have been identified as culprits. This led to the introduction of newer, potentially safer, and more effective antiplatelet agents (prasugrel and ticagrelor). Additionally, several point-of-care assays of platelet function have been developed in recent years to rapidly screen individuals on antiplatelet therapy. While the routine use of platelet function testing is uncertain and not currently recommended, it may be useful in instances when the degree of platelet inhibition may be uncertain such as high-risk patients undergoing percutaneous coronary intervention or when there may be a suspected pharmacodynamic interaction with other drugs. The current paper focuses on the P2Y12 receptor inhibitors and their pharmacogenetics and indications in patients with acute coronary syndromes or receiving percutaneous coronary interventions as well as the applicability of platelet function testing in this clinical context.http://dx.doi.org/10.1155/2013/195456 |
| spellingShingle | Adriana Dana Oprea Wanda M. Popescu Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? Cardiology Research and Practice |
| title | Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? |
| title_full | Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? |
| title_fullStr | Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? |
| title_full_unstemmed | Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? |
| title_short | Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? |
| title_sort | receptor inhibitors in acute coronary syndromes what is new on the horizon |
| url | http://dx.doi.org/10.1155/2013/195456 |
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