Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®
Aim. To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods. CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/8424628 |
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| author | Jan de Laffolie Martin W. Laass Dietmar Scholz Klaus-Peter Zimmer Stephan Buderus CEDATA-GPGE Study Group |
| author_facet | Jan de Laffolie Martin W. Laass Dietmar Scholz Klaus-Peter Zimmer Stephan Buderus CEDATA-GPGE Study Group |
| author_sort | Jan de Laffolie |
| collection | DOAJ |
| description | Aim. To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods. CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1–5; 1 = very good) and physicians’ general assessment (0 = no activity to 4 = severe disease) and the disease indices. Anemia was defined as hemoglobin concentration below the 3rd percentile. Results. Prevalence of anemia was 65.2% in CD and 60.2% in UC. Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average ± standard deviation; CD: 3.0 ± 0.9 versus 2.5 ± 0.9, p<0.0001; UC: 2.9 ± 0.9 versus 2.3 ± 0.9, p<0.0001). Accordingly, physicians’ general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD (p<0.0001) and UC (p<0.0001). PCDAI in anemic CD, p<0.0001, and PUCAI in anemic UC patients, p<0.0001, were significantly higher than in nonanemic patients. 40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up. Conclusion. Almost 2/3 of pediatric IBD patients are anemic. Patients’ self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients. Contrastingly, only a minority received iron therapy. |
| format | Article |
| id | doaj-art-42b1d782bcef45a1a0deb9a2f2721114 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-42b1d782bcef45a1a0deb9a2f27211142025-02-03T07:25:38ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/84246288424628Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®Jan de Laffolie0Martin W. Laass1Dietmar Scholz2Klaus-Peter Zimmer3Stephan Buderus4CEDATA-GPGE Study Group5General Pediatrics & Neonatology, Justus-Liebig-University, Giessen, GermanyDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyDepartment of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, GermanyGeneral Pediatrics & Neonatology, Justus-Liebig-University, Giessen, GermanyPediatric and Adolescent Medicine, GFO Kliniken Bonn, St. Marien-Hospital, Bonn, GermanyGesellschaft für pädiatrische Gastroenterologie und Ernährung, Chausseestr 128-129, Berlin, GermanyAim. To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods. CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1–5; 1 = very good) and physicians’ general assessment (0 = no activity to 4 = severe disease) and the disease indices. Anemia was defined as hemoglobin concentration below the 3rd percentile. Results. Prevalence of anemia was 65.2% in CD and 60.2% in UC. Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average ± standard deviation; CD: 3.0 ± 0.9 versus 2.5 ± 0.9, p<0.0001; UC: 2.9 ± 0.9 versus 2.3 ± 0.9, p<0.0001). Accordingly, physicians’ general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD (p<0.0001) and UC (p<0.0001). PCDAI in anemic CD, p<0.0001, and PUCAI in anemic UC patients, p<0.0001, were significantly higher than in nonanemic patients. 40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up. Conclusion. Almost 2/3 of pediatric IBD patients are anemic. Patients’ self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients. Contrastingly, only a minority received iron therapy.http://dx.doi.org/10.1155/2017/8424628 |
| spellingShingle | Jan de Laffolie Martin W. Laass Dietmar Scholz Klaus-Peter Zimmer Stephan Buderus CEDATA-GPGE Study Group Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® Gastroenterology Research and Practice |
| title | Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® |
| title_full | Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® |
| title_fullStr | Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® |
| title_full_unstemmed | Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® |
| title_short | Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE® |
| title_sort | prevalence of anemia in pediatric ibd patients and impact on disease severity results of the pediatric ibd registry cedata gpge r |
| url | http://dx.doi.org/10.1155/2017/8424628 |
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