Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction
Background: Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men. Objectives: This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI....
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | JACC: Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772963X2400810X |
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| author | Tanya M. Spruill, PhD Chorong Park, PhD, RN Jolaade Kalinowski, EdD Milla E. Arabadjian, PhD, RN Yuhe Xia, MSc Amanda J. Shallcross, ND, MPH Pallavi Visvanathan, PhD Nathaniel R. Smilowitz, MD, MS Anaïs Hausvater, MD Sripal Bangalore, MD, MHA Hua Zhong, PhD Ki Park, MD Puja K. Mehta, MD Dwithiya K. Thomas, MD Jeffrey Trost, MD Kevin R. Bainey, MD Bobak Heydari, MD Janet Wei, MD Victoria Vaughan Dickson, PhD, RN Gbenga Ogedegbe, MD, MPH Jeffrey S. Berger, MD, MS Judith S. Hochman, MD Harmony R. Reynolds, MD |
| author_facet | Tanya M. Spruill, PhD Chorong Park, PhD, RN Jolaade Kalinowski, EdD Milla E. Arabadjian, PhD, RN Yuhe Xia, MSc Amanda J. Shallcross, ND, MPH Pallavi Visvanathan, PhD Nathaniel R. Smilowitz, MD, MS Anaïs Hausvater, MD Sripal Bangalore, MD, MHA Hua Zhong, PhD Ki Park, MD Puja K. Mehta, MD Dwithiya K. Thomas, MD Jeffrey Trost, MD Kevin R. Bainey, MD Bobak Heydari, MD Janet Wei, MD Victoria Vaughan Dickson, PhD, RN Gbenga Ogedegbe, MD, MPH Jeffrey S. Berger, MD, MS Judith S. Hochman, MD Harmony R. Reynolds, MD |
| author_sort | Tanya M. Spruill, PhD |
| collection | DOAJ |
| description | Background: Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men. Objectives: This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI. Methods: Women with elevated stress (Perceived Stress Scale [PSS-4]≥6) at least 2 months after MI were enrolled from 12 hospitals in the United States and Canada and via community advertising. Participants were randomized to a remotely delivered mindfulness intervention (MBCT-Brief) or heart disease education, both 8 weeks long. Follow-up was 6 months. Changes in stress (PSS-10; primary outcome) and secondary outcomes (depressive symptoms, anxiety, quality of life, disease-specific health status, actigraphy-assessed sleep) were compared between groups. Results: The sample included 130 women with MI (mean age 59.8 ± 12.8 years, 34% racial/ethnic minorities). In intention-to-treat analysis, PSS-10 scores declined in the MBCT-Brief arm (−0.52 [95% CI: −0.77 to −0.28]) but not the heart disease education arm (−0.19 [95% CI: −0.45 to 0.06]; group×time interaction P = 0.070). The effect was stronger in per-protocol analysis of participants who completed ≥4 intervention sessions (P = 0.049). There were no significant differences in secondary outcomes in intention-to-treat or per-protocol analyses. Within the MBCT-Brief arm, more frequent mindfulness practice was associated with greater reductions in stress (P = 0.007), depressive symptoms (P = 0.017), and anxiety (P = 0.036). Conclusions: MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to engage women with MI in mindfulness training and support regular home practice may enhance these effects. |
| format | Article |
| id | doaj-art-42961af3ee7f41a7ab11697ce4b2e637 |
| institution | Kabale University |
| issn | 2772-963X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Advances |
| spelling | doaj-art-42961af3ee7f41a7ab11697ce4b2e6372025-01-18T05:05:38ZengElsevierJACC: Advances2772-963X2025-02-0142101530Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial InfarctionTanya M. Spruill, PhD0Chorong Park, PhD, RN1Jolaade Kalinowski, EdD2Milla E. Arabadjian, PhD, RN3Yuhe Xia, MSc4Amanda J. Shallcross, ND, MPH5Pallavi Visvanathan, PhD6Nathaniel R. Smilowitz, MD, MS7Anaïs Hausvater, MD8Sripal Bangalore, MD, MHA9Hua Zhong, PhD10Ki Park, MD11Puja K. Mehta, MD12Dwithiya K. Thomas, MD13Jeffrey Trost, MD14Kevin R. Bainey, MD15Bobak Heydari, MD16Janet Wei, MD17Victoria Vaughan Dickson, PhD, RN18Gbenga Ogedegbe, MD, MPH19Jeffrey S. Berger, MD, MS20Judith S. Hochman, MD21Harmony R. Reynolds, MD22Institute for Excellence in Health Equity, NYU Langone Health, New York, New York, USA; Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA; Sarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USA; Address for correspondence: Dr Tanya M. Spruill, Institute for Excellence in Health Equity, NYU Langone Health, 180 Madison Avenue, 7th Floor, New York, New York 10016, USA.Seoul National University College of Nursing, Seoul, South KoreaDepartment of Human Development and Family Sciences, University of Connecticut, Storrs, Connecticut, USADepartment of Foundations of Medicine, NYU Grossman Long Island School of Medicine, New York, New York, USADepartment of Population Health, NYU Grossman School of Medicine, New York, New York, USADepartment of Wellness and Preventive Medicine, Cleveland Clinic, Cleveland, Ohio, USAManhattan Center for Mindfulness-Based Cognitive Behavioral Therapy, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USADepartment of Population Health, NYU Grossman School of Medicine, New York, New York, USAUniversity of Florida, Gainesville, Florida, USAEmory Women’s Heart Center, Emory University School of Medicine, Atlanta, Georgia, USASt. Lukes University Health System, Bethlehem, Pennsylvania, USAJohns Hopkins Medical Center, Baltimore, Maryland, USAMazankowski Alberta Heart Institute, University of Alberta, Edmonton, CanadaBrigham and Women’s Hospital, HMS, Boston, Massachusetts, USABarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USAUniversity of Connecticut School of Nursing, Storrs, Connecticut, USAInstitute for Excellence in Health Equity, NYU Langone Health, New York, New York, USA; Department of Population Health, NYU Grossman School of Medicine, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USASarah Ross Soter Center for Women’s Cardiovascular Research, NYU Grossman School of Medicine, New York, New York, USABackground: Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men. Objectives: This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI. Methods: Women with elevated stress (Perceived Stress Scale [PSS-4]≥6) at least 2 months after MI were enrolled from 12 hospitals in the United States and Canada and via community advertising. Participants were randomized to a remotely delivered mindfulness intervention (MBCT-Brief) or heart disease education, both 8 weeks long. Follow-up was 6 months. Changes in stress (PSS-10; primary outcome) and secondary outcomes (depressive symptoms, anxiety, quality of life, disease-specific health status, actigraphy-assessed sleep) were compared between groups. Results: The sample included 130 women with MI (mean age 59.8 ± 12.8 years, 34% racial/ethnic minorities). In intention-to-treat analysis, PSS-10 scores declined in the MBCT-Brief arm (−0.52 [95% CI: −0.77 to −0.28]) but not the heart disease education arm (−0.19 [95% CI: −0.45 to 0.06]; group×time interaction P = 0.070). The effect was stronger in per-protocol analysis of participants who completed ≥4 intervention sessions (P = 0.049). There were no significant differences in secondary outcomes in intention-to-treat or per-protocol analyses. Within the MBCT-Brief arm, more frequent mindfulness practice was associated with greater reductions in stress (P = 0.007), depressive symptoms (P = 0.017), and anxiety (P = 0.036). Conclusions: MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to engage women with MI in mindfulness training and support regular home practice may enhance these effects.http://www.sciencedirect.com/science/article/pii/S2772963X2400810Xmyocardial infarctionwomenstressmindfulnessclinical trial |
| spellingShingle | Tanya M. Spruill, PhD Chorong Park, PhD, RN Jolaade Kalinowski, EdD Milla E. Arabadjian, PhD, RN Yuhe Xia, MSc Amanda J. Shallcross, ND, MPH Pallavi Visvanathan, PhD Nathaniel R. Smilowitz, MD, MS Anaïs Hausvater, MD Sripal Bangalore, MD, MHA Hua Zhong, PhD Ki Park, MD Puja K. Mehta, MD Dwithiya K. Thomas, MD Jeffrey Trost, MD Kevin R. Bainey, MD Bobak Heydari, MD Janet Wei, MD Victoria Vaughan Dickson, PhD, RN Gbenga Ogedegbe, MD, MPH Jeffrey S. Berger, MD, MS Judith S. Hochman, MD Harmony R. Reynolds, MD Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction JACC: Advances myocardial infarction women stress mindfulness clinical trial |
| title | Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction |
| title_full | Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction |
| title_fullStr | Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction |
| title_full_unstemmed | Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction |
| title_short | Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction |
| title_sort | brief mindfulness based cognitive therapy in women with myocardial infarction |
| topic | myocardial infarction women stress mindfulness clinical trial |
| url | http://www.sciencedirect.com/science/article/pii/S2772963X2400810X |
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