Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios
The increasing use of plastic food containers, particularly for pre-cooked meals and takeout services, has raised concerns regarding the potential health risks associated with plastic leachates. This study investigated the impact of leachates from heat-treated polypropylene (PP) plastic food contain...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015744 |
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| author | Hu Liu Peiqi Li Tan Zhou Ziqi Yu Weigao Zhang Yunfeng Zhu Jiayi Xu Xiaoxiao Wu Jing Li Chi Zhang Lei Chen Dan Weng |
| author_facet | Hu Liu Peiqi Li Tan Zhou Ziqi Yu Weigao Zhang Yunfeng Zhu Jiayi Xu Xiaoxiao Wu Jing Li Chi Zhang Lei Chen Dan Weng |
| author_sort | Hu Liu |
| collection | DOAJ |
| description | The increasing use of plastic food containers, particularly for pre-cooked meals and takeout services, has raised concerns regarding the potential health risks associated with plastic leachates. This study investigated the impact of leachates from heat-treated polypropylene (PP) plastic food containers on glucose and lipid metabolism using both in vitro and in vivo models. AML12 hepatocytes exposed to leachates from three different PP plastic containers exhibited significant disruptions in the homeostasis of lipid and glucose metabolism, evidenced by increased intracellular lipid content and altered gene expression related to lipogenesis, lipid uptake, lipolysis, and fatty acid β-oxidation. C57BL/6J mice were fed with the mouse diet that had been heated in two distinct types of PP plastic food containers for 8 weeks and these mice exhibited accelerated body weight gain, altered fasting blood glucose levels, and changes in serum lipid profiles. Histological analysis revealed increased adipocyte size, liver steatosis, and glycogen accumulation. Transcriptome sequencing of liver tissues highlighted significant alterations in the expression of genes involved in metabolic pathways, further corroborated by real-time qPCR validation. These findings underscore the potential metabolic health risks posed by the use of heated plastic food containers. |
| format | Article |
| id | doaj-art-4291ec05268644dfb7cd2e1f315a3cbc |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-4291ec05268644dfb7cd2e1f315a3cbc2025-01-23T05:25:47ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117498Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenariosHu Liu0Peiqi Li1Tan Zhou2Ziqi Yu3Weigao Zhang4Yunfeng Zhu5Jiayi Xu6Xiaoxiao Wu7Jing Li8Chi Zhang9Lei Chen10Dan Weng11School of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaShanghai Yangpu District Central Hospital (Tongji University Affiliated Yangpu Hospital), No. 450 Tengyue Road, Yangpu District, Shanghai, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaKey Laboratory of Biotoxin Analysis & Assessment, State Administration for Market Regulation, Nanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaSchool of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, ChinaKey Laboratory of Biotoxin Analysis & Assessment, State Administration for Market Regulation, Nanjing Institute of Product Quality Inspection, Nanjing 210019, China; Correspondence to: Key Laboratory of Biotoxin Analysis & Assessment, State Administration for Market Regulation, Nanjing Institute of Product Quality Inspection, Nanjing 210019, China.Department of Neurovascular Center, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai 200433, China; Corresponding author.School of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China; Correspondence to: School of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing, China.The increasing use of plastic food containers, particularly for pre-cooked meals and takeout services, has raised concerns regarding the potential health risks associated with plastic leachates. This study investigated the impact of leachates from heat-treated polypropylene (PP) plastic food containers on glucose and lipid metabolism using both in vitro and in vivo models. AML12 hepatocytes exposed to leachates from three different PP plastic containers exhibited significant disruptions in the homeostasis of lipid and glucose metabolism, evidenced by increased intracellular lipid content and altered gene expression related to lipogenesis, lipid uptake, lipolysis, and fatty acid β-oxidation. C57BL/6J mice were fed with the mouse diet that had been heated in two distinct types of PP plastic food containers for 8 weeks and these mice exhibited accelerated body weight gain, altered fasting blood glucose levels, and changes in serum lipid profiles. Histological analysis revealed increased adipocyte size, liver steatosis, and glycogen accumulation. Transcriptome sequencing of liver tissues highlighted significant alterations in the expression of genes involved in metabolic pathways, further corroborated by real-time qPCR validation. These findings underscore the potential metabolic health risks posed by the use of heated plastic food containers.http://www.sciencedirect.com/science/article/pii/S0147651324015744LeachatesPlastic food containersLipid metabolismGlucose metabolism |
| spellingShingle | Hu Liu Peiqi Li Tan Zhou Ziqi Yu Weigao Zhang Yunfeng Zhu Jiayi Xu Xiaoxiao Wu Jing Li Chi Zhang Lei Chen Dan Weng Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios Ecotoxicology and Environmental Safety Leachates Plastic food containers Lipid metabolism Glucose metabolism |
| title | Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios |
| title_full | Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios |
| title_fullStr | Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios |
| title_full_unstemmed | Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios |
| title_short | Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios |
| title_sort | exposure to leachates of plastic food containers disturbs glucose and lipid metabolism insights from models mimicking real exposure scenarios |
| topic | Leachates Plastic food containers Lipid metabolism Glucose metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015744 |
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