Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes
Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/308535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556137078063104 |
|---|---|
| author | Ashish Thapliyal Rashmi Verma Navin Kumar |
| author_facet | Ashish Thapliyal Rashmi Verma Navin Kumar |
| author_sort | Ashish Thapliyal |
| collection | DOAJ |
| description | Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GTPases have been reported to prevent the aberrant cell growth and induce apoptosis in cell lines. Present review focuses on role of these two monomeric GTPases and summarizes their role in pathophysiological processes. |
| format | Article |
| id | doaj-art-428c283a02e1492c9f1d781fac3f1f88 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-428c283a02e1492c9f1d781fac3f1f882025-02-03T05:46:16ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/308535308535Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological ProcessesAshish Thapliyal0Rashmi Verma1Navin Kumar2Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, IndiaDepartment of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, IndiaDepartment of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, IndiaDexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GTPases have been reported to prevent the aberrant cell growth and induce apoptosis in cell lines. Present review focuses on role of these two monomeric GTPases and summarizes their role in pathophysiological processes.http://dx.doi.org/10.1155/2014/308535 |
| spellingShingle | Ashish Thapliyal Rashmi Verma Navin Kumar Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes International Journal of Cell Biology |
| title | Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes |
| title_full | Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes |
| title_fullStr | Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes |
| title_full_unstemmed | Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes |
| title_short | Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes |
| title_sort | small g proteins dexras1 and rhes and their role in pathophysiological processes |
| url | http://dx.doi.org/10.1155/2014/308535 |
| work_keys_str_mv | AT ashishthapliyal smallgproteinsdexras1andrhesandtheirroleinpathophysiologicalprocesses AT rashmiverma smallgproteinsdexras1andrhesandtheirroleinpathophysiologicalprocesses AT navinkumar smallgproteinsdexras1andrhesandtheirroleinpathophysiologicalprocesses |