Nongenomic Mechanisms of PTEN Regulation
A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cel...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/379685 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568065745747968 |
|---|---|
| author | Jimmie E. Fata Shawon Debnath Edmund C. Jenkins Marcia V. Fournier |
| author_facet | Jimmie E. Fata Shawon Debnath Edmund C. Jenkins Marcia V. Fournier |
| author_sort | Jimmie E. Fata |
| collection | DOAJ |
| description | A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events. |
| format | Article |
| id | doaj-art-427e906aec29432fb8d7e199f883d9f1 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-427e906aec29432fb8d7e199f883d9f12025-02-03T00:59:49ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/379685379685Nongenomic Mechanisms of PTEN RegulationJimmie E. Fata0Shawon Debnath1Edmund C. Jenkins2Marcia V. Fournier3Department of Biology, College of Staten Island, 2800 Victory Boulevard, Staten Island, NY 10314, USADepartment of Biology, College of Staten Island, 2800 Victory Boulevard, Staten Island, NY 10314, USADepartment of Biology, College of Staten Island, 2800 Victory Boulevard, Staten Island, NY 10314, USABIOARRAY Therapeutics Inc., Venture Development Center, UMASS, 100 Morrissey Boulevard, Boston, MA 02125, USAA large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.http://dx.doi.org/10.1155/2012/379685 |
| spellingShingle | Jimmie E. Fata Shawon Debnath Edmund C. Jenkins Marcia V. Fournier Nongenomic Mechanisms of PTEN Regulation International Journal of Cell Biology |
| title | Nongenomic Mechanisms of PTEN Regulation |
| title_full | Nongenomic Mechanisms of PTEN Regulation |
| title_fullStr | Nongenomic Mechanisms of PTEN Regulation |
| title_full_unstemmed | Nongenomic Mechanisms of PTEN Regulation |
| title_short | Nongenomic Mechanisms of PTEN Regulation |
| title_sort | nongenomic mechanisms of pten regulation |
| url | http://dx.doi.org/10.1155/2012/379685 |
| work_keys_str_mv | AT jimmieefata nongenomicmechanismsofptenregulation AT shawondebnath nongenomicmechanismsofptenregulation AT edmundcjenkins nongenomicmechanismsofptenregulation AT marciavfournier nongenomicmechanismsofptenregulation |