Interstitial Granulomatous Drug Reaction to Ustekinumab
Interstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/1461145 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550752712654848 |
|---|---|
| author | A. Walker J. S. Westerdahl J. Zussman J. Mathis |
| author_facet | A. Walker J. S. Westerdahl J. Zussman J. Mathis |
| author_sort | A. Walker |
| collection | DOAJ |
| description | Interstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE inhibitors, antihistamines, beta-blockers, antidepressants, and anticonvulsants. Ustekinumab is a human monoclonal antibody that targets inflammatory cytokines IL-12 and IL-23 and has been have shown to be effective in treating IGDR. However, we present a case that suggests ustekinumab can also act as an inciting agent for IGDR. |
| format | Article |
| id | doaj-art-427acb34ef29479589bd2a86dd831bea |
| institution | Kabale University |
| issn | 2090-6471 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-427acb34ef29479589bd2a86dd831bea2025-02-03T06:05:54ZengWileyCase Reports in Dermatological Medicine2090-64712022-01-01202210.1155/2022/1461145Interstitial Granulomatous Drug Reaction to UstekinumabA. Walker0J. S. Westerdahl1J. Zussman2J. Mathis3University of Utah School of MedicineUniversity of Utah School of MedicineUniversity of UtahUniversity of UtahInterstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE inhibitors, antihistamines, beta-blockers, antidepressants, and anticonvulsants. Ustekinumab is a human monoclonal antibody that targets inflammatory cytokines IL-12 and IL-23 and has been have shown to be effective in treating IGDR. However, we present a case that suggests ustekinumab can also act as an inciting agent for IGDR.http://dx.doi.org/10.1155/2022/1461145 |
| spellingShingle | A. Walker J. S. Westerdahl J. Zussman J. Mathis Interstitial Granulomatous Drug Reaction to Ustekinumab Case Reports in Dermatological Medicine |
| title | Interstitial Granulomatous Drug Reaction to Ustekinumab |
| title_full | Interstitial Granulomatous Drug Reaction to Ustekinumab |
| title_fullStr | Interstitial Granulomatous Drug Reaction to Ustekinumab |
| title_full_unstemmed | Interstitial Granulomatous Drug Reaction to Ustekinumab |
| title_short | Interstitial Granulomatous Drug Reaction to Ustekinumab |
| title_sort | interstitial granulomatous drug reaction to ustekinumab |
| url | http://dx.doi.org/10.1155/2022/1461145 |
| work_keys_str_mv | AT awalker interstitialgranulomatousdrugreactiontoustekinumab AT jswesterdahl interstitialgranulomatousdrugreactiontoustekinumab AT jzussman interstitialgranulomatousdrugreactiontoustekinumab AT jmathis interstitialgranulomatousdrugreactiontoustekinumab |