Boost IORT in Breast Cancer: Body of Evidence
The term IORT (intraoperative radiotherapy) is currently used for various techniques that show decisive differences in dose delivery. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments with single doses around 10 Gy, provid...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/472516 |
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| author | Felix Sedlmayer Roland Reitsamer Christoph Fussl Ingrid Ziegler Franz Zehentmayr Heinz Deutschmann Peter Kopp Gerd Fastner |
| author_facet | Felix Sedlmayer Roland Reitsamer Christoph Fussl Ingrid Ziegler Franz Zehentmayr Heinz Deutschmann Peter Kopp Gerd Fastner |
| author_sort | Felix Sedlmayer |
| collection | DOAJ |
| description | The term IORT (intraoperative radiotherapy) is currently used for various techniques that show decisive differences in dose delivery. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments with single doses around 10 Gy, providing outstandingly low local recurrence rates in any risk constellation also at long term analyses. Compared to other boost methods, an intraoperative treatment has evident advantages as follows. Precision. Direct visualisation of the tumour bed during surgery guarantees an accurate dose delivery. This fact has additionally gained importance in times of primary reconstruction techniques after lumpectomy to optimise cosmetic outcome. IORT is performed before breast tissue is mobilised for plastic purposes. Cosmesis. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Patient Comfort. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with a 3-week hypofractionated external beam radiotherapy to the whole breast (WBI) is presently tested in the HIOB trial (hypofractionated WBI preceded by IORT electron boost), a prospective multicenter trial of the International Society of Intraoperative Radiotherapy (ISIORT). |
| format | Article |
| id | doaj-art-424f41f940ae4aa5910de03ad890ebfa |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-424f41f940ae4aa5910de03ad890ebfa2025-02-03T07:25:48ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/472516472516Boost IORT in Breast Cancer: Body of EvidenceFelix Sedlmayer0Roland Reitsamer1Christoph Fussl2Ingrid Ziegler3Franz Zehentmayr4Heinz Deutschmann5Peter Kopp6Gerd Fastner7Department of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Special Gynecology and Breast Center, General Hospital, Paracelsus Medical University Clinics, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Radiotherapy and Radio-Oncology, LKH Salzburg, General Hospital, Paracelsus Medical University Clinics, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaThe term IORT (intraoperative radiotherapy) is currently used for various techniques that show decisive differences in dose delivery. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments with single doses around 10 Gy, providing outstandingly low local recurrence rates in any risk constellation also at long term analyses. Compared to other boost methods, an intraoperative treatment has evident advantages as follows. Precision. Direct visualisation of the tumour bed during surgery guarantees an accurate dose delivery. This fact has additionally gained importance in times of primary reconstruction techniques after lumpectomy to optimise cosmetic outcome. IORT is performed before breast tissue is mobilised for plastic purposes. Cosmesis. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Patient Comfort. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with a 3-week hypofractionated external beam radiotherapy to the whole breast (WBI) is presently tested in the HIOB trial (hypofractionated WBI preceded by IORT electron boost), a prospective multicenter trial of the International Society of Intraoperative Radiotherapy (ISIORT).http://dx.doi.org/10.1155/2014/472516 |
| spellingShingle | Felix Sedlmayer Roland Reitsamer Christoph Fussl Ingrid Ziegler Franz Zehentmayr Heinz Deutschmann Peter Kopp Gerd Fastner Boost IORT in Breast Cancer: Body of Evidence International Journal of Breast Cancer |
| title | Boost IORT in Breast Cancer: Body of Evidence |
| title_full | Boost IORT in Breast Cancer: Body of Evidence |
| title_fullStr | Boost IORT in Breast Cancer: Body of Evidence |
| title_full_unstemmed | Boost IORT in Breast Cancer: Body of Evidence |
| title_short | Boost IORT in Breast Cancer: Body of Evidence |
| title_sort | boost iort in breast cancer body of evidence |
| url | http://dx.doi.org/10.1155/2014/472516 |
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