Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model
Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily calor...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/136502 |
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| author | Shuichi Ohtomo Yuko Izuhara Masaomi Nangaku Takashi Dan Sadayoshi Ito Charles van Ypersele de Strihou Toshio Miyata |
| author_facet | Shuichi Ohtomo Yuko Izuhara Masaomi Nangaku Takashi Dan Sadayoshi Ito Charles van Ypersele de Strihou Toshio Miyata |
| author_sort | Shuichi Ohtomo |
| collection | DOAJ |
| description | Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels. |
| format | Article |
| id | doaj-art-424b6c54cd334f0a89e1a5981ea5e7df |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-424b6c54cd334f0a89e1a5981ea5e7df2025-02-03T05:53:44ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/136502136502Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat ModelShuichi Ohtomo0Yuko Izuhara1Masaomi Nangaku2Takashi Dan3Sadayoshi Ito4Charles van Ypersele de Strihou5Toshio Miyata6Research Division, Chugai Pharmaceutical Co., LTD., Shizuoka 412-8513, JapanInstitute of Medical Sciences, Tokai University, Kanagawa 259-1193, JapanDivision of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo 113-8655, JapanCenter for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanDepartment of Nephrology, Hypertension and Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanService de Nephrologie, Universite Catholique de Louvain, 1200 Brussels, BelgiumCenter for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanObesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.http://dx.doi.org/10.1155/2010/136502 |
| spellingShingle | Shuichi Ohtomo Yuko Izuhara Masaomi Nangaku Takashi Dan Sadayoshi Ito Charles van Ypersele de Strihou Toshio Miyata Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model Journal of Obesity |
| title | Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model |
| title_full | Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model |
| title_fullStr | Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model |
| title_full_unstemmed | Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model |
| title_short | Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model |
| title_sort | body weight control by a high carbohydrate low fat diet slows the progression of diabetic kidney damage in an obese hypertensive type 2 diabetic rat model |
| url | http://dx.doi.org/10.1155/2010/136502 |
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