Filamentous chemokine CCL5 structure and the functional aspects

Filamentous chemokine CCL5 structure and the functional aspects

Abstract Human inflammation-related CC chemokine ligand 5 (hCCL5) has significant self-assembly property under physiological conditions. The mechanism and function of hCCL5 oligomerization remain unclear. Different intermolecular interactions, such as E66-K25 or E66-R44/K45, have been reported to me...

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Main Authors: Yi-Ting Yuan, Tzu-Ching Guo, Chu-Ya Wu, Yi-Qi Yeh, Ching‑Tse Wu, Shu-Yao Hsu, Zi-Wen Weng, Meng-Ru Ho, Shang-Te Danny Hsu, Yi-Chen Chen, Chuang‑Rung Chang, Kuen-Phon Wu, U-Ser Jeng, Shih-Che Sue
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Chemokine CCL5
Filament
cryo-EM
SWAXS
NMR
Chemokine secretion
Online Access:https://doi.org/10.1038/s41598-025-98114-9
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