Familial Prevalence of Inflammatory Bowel Disease in Northern Alberta
Previous studies have reported a high prevalence of inflammatory bowel disease among the relatives, and especially siblings, of patients with Crohn's disease or ulcerative colitis. This high familial prevalence of Crohn's disease and ulcerative colitis suggests that genetic factors could p...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/625269 |
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| Summary: | Previous studies have reported a high prevalence of inflammatory
bowel disease among the relatives, and especially siblings, of patients with
Crohn's disease or ulcerative colitis. This high familial prevalence of Crohn's
disease and ulcerative colitis suggests that genetic factors could play a role in the
development of these disorders. The present study attempted to assess the relative
risk for relatives of Crohn's disease and ulcerative colitis patients based on data
provided by 1015 questionnaires completed by patients in northern Alberta. A Mx2 2x2 test among relatives was performed on the diseased versus normal data for
each diagnosis to determine if significant differences existed. The prevalence for
mothers and sisters was the highest of the relative groups for Crohn's disease
( 6430 of 105 and 4670 of 105 , respectively). Female relatives tended to have twice
the prevalence of their male counterparts. There were differences between
mother, daughter and sister prevalence rates for Crohn's disease. These results
support the hypothesis that a genetic predisposition in families combined with
possible environmental and lifestyle influences determine the relative risk of
developing Crohn's disease and ulcerative colitis. |
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| ISSN: | 0835-7900 |