Genetics of Human and Canine Dilated Cardiomyopathy
Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2015/204823 |
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| author | Siobhan Simpson Jennifer Edwards Thomas F. N. Ferguson-Mignan Malcolm Cobb Nigel P. Mongan Catrin S. Rutland |
| author_facet | Siobhan Simpson Jennifer Edwards Thomas F. N. Ferguson-Mignan Malcolm Cobb Nigel P. Mongan Catrin S. Rutland |
| author_sort | Siobhan Simpson |
| collection | DOAJ |
| description | Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed. |
| format | Article |
| id | doaj-art-42385d0d65f548699d74e0d2f19e15b2 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-42385d0d65f548699d74e0d2f19e15b22025-02-03T05:59:11ZengWileyInternational Journal of Genomics2314-436X2314-43782015-01-01201510.1155/2015/204823204823Genetics of Human and Canine Dilated CardiomyopathySiobhan Simpson0Jennifer Edwards1Thomas F. N. Ferguson-Mignan2Malcolm Cobb3Nigel P. Mongan4Catrin S. Rutland5Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKCardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed.http://dx.doi.org/10.1155/2015/204823 |
| spellingShingle | Siobhan Simpson Jennifer Edwards Thomas F. N. Ferguson-Mignan Malcolm Cobb Nigel P. Mongan Catrin S. Rutland Genetics of Human and Canine Dilated Cardiomyopathy International Journal of Genomics |
| title | Genetics of Human and Canine Dilated Cardiomyopathy |
| title_full | Genetics of Human and Canine Dilated Cardiomyopathy |
| title_fullStr | Genetics of Human and Canine Dilated Cardiomyopathy |
| title_full_unstemmed | Genetics of Human and Canine Dilated Cardiomyopathy |
| title_short | Genetics of Human and Canine Dilated Cardiomyopathy |
| title_sort | genetics of human and canine dilated cardiomyopathy |
| url | http://dx.doi.org/10.1155/2015/204823 |
| work_keys_str_mv | AT siobhansimpson geneticsofhumanandcaninedilatedcardiomyopathy AT jenniferedwards geneticsofhumanandcaninedilatedcardiomyopathy AT thomasfnfergusonmignan geneticsofhumanandcaninedilatedcardiomyopathy AT malcolmcobb geneticsofhumanandcaninedilatedcardiomyopathy AT nigelpmongan geneticsofhumanandcaninedilatedcardiomyopathy AT catrinsrutland geneticsofhumanandcaninedilatedcardiomyopathy |