Granulomatous Hepatitis in Association with Fever and a Palmar Rash
Secondary syphilis may present without the classical features of the disease and should be considered in patients acutely ill with abnormal liver function tests and a nonspecific pattern on liver biopsy. Secondary syphilis may present in association with granulomatous hepatitis and serological testi...
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| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1987-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1987/647463 |
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| _version_ | 1832551528195424256 |
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| author | Desmond J Leddin James A Barrowman |
| author_facet | Desmond J Leddin James A Barrowman |
| author_sort | Desmond J Leddin |
| collection | DOAJ |
| description | Secondary syphilis may present without the classical features of the
disease and should be considered in patients acutely ill with abnormal liver function
tests and a nonspecific pattern on liver biopsy. Secondary syphilis may present in
association with granulomatous hepatitis and serological testing should be performed
if the etiology of the hepatic granulomas is unclear. While the finding of a disproportionate
elevation of alkaline phosphatase relative to serum bilirubin may be a useful
pointer towards the diagnosis this pattern is not specific and not consistently observed.
The definitive answer to the question of whether syphilitic hepatitis exists awaits the
development of comprehensive rests to exclude viral pathogens. |
| format | Article |
| id | doaj-art-4228982c913040839cf3b176040609fe |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1987-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4228982c913040839cf3b176040609fe2025-02-03T06:01:15ZengWileyCanadian Journal of Gastroenterology0835-79001987-01-0111374010.1155/1987/647463Granulomatous Hepatitis in Association with Fever and a Palmar RashDesmond J LeddinJames A BarrowmanSecondary syphilis may present without the classical features of the disease and should be considered in patients acutely ill with abnormal liver function tests and a nonspecific pattern on liver biopsy. Secondary syphilis may present in association with granulomatous hepatitis and serological testing should be performed if the etiology of the hepatic granulomas is unclear. While the finding of a disproportionate elevation of alkaline phosphatase relative to serum bilirubin may be a useful pointer towards the diagnosis this pattern is not specific and not consistently observed. The definitive answer to the question of whether syphilitic hepatitis exists awaits the development of comprehensive rests to exclude viral pathogens.http://dx.doi.org/10.1155/1987/647463 |
| spellingShingle | Desmond J Leddin James A Barrowman Granulomatous Hepatitis in Association with Fever and a Palmar Rash Canadian Journal of Gastroenterology |
| title | Granulomatous Hepatitis in Association with Fever and a Palmar Rash |
| title_full | Granulomatous Hepatitis in Association with Fever and a Palmar Rash |
| title_fullStr | Granulomatous Hepatitis in Association with Fever and a Palmar Rash |
| title_full_unstemmed | Granulomatous Hepatitis in Association with Fever and a Palmar Rash |
| title_short | Granulomatous Hepatitis in Association with Fever and a Palmar Rash |
| title_sort | granulomatous hepatitis in association with fever and a palmar rash |
| url | http://dx.doi.org/10.1155/1987/647463 |
| work_keys_str_mv | AT desmondjleddin granulomatoushepatitisinassociationwithfeverandapalmarrash AT jamesabarrowman granulomatoushepatitisinassociationwithfeverandapalmarrash |