Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study
Background. Diaphanous related formin 1 (DIAPH1) is a novel component of advanced glycation end product (AGE) signal transduction that was recently found to participate in diabetes-related disorders, obesity, and androgen hormones. We investigated whether plasma DIAPH1 levels were a potential progno...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/9620423 |
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| author | Xing Li Mingyu Liao Jiaqing Shao Weixin Li Liu Shi Dong Wang Juan Ni Qiuyue Shen Fan Yang Guiliang Peng Ling Zhou Yuling Zhang Zheng Sun Hongting Zheng Min Long |
| author_facet | Xing Li Mingyu Liao Jiaqing Shao Weixin Li Liu Shi Dong Wang Juan Ni Qiuyue Shen Fan Yang Guiliang Peng Ling Zhou Yuling Zhang Zheng Sun Hongting Zheng Min Long |
| author_sort | Xing Li |
| collection | DOAJ |
| description | Background. Diaphanous related formin 1 (DIAPH1) is a novel component of advanced glycation end product (AGE) signal transduction that was recently found to participate in diabetes-related disorders, obesity, and androgen hormones. We investigated whether plasma DIAPH1 levels were a potential prognostic predictor for polycystic ovary syndrome (PCOS). Methods. The levels of circulating plasma DIAPH1 and indicators of glucose, insulin, lipid metabolism, liver enzymes, kidney function, sex hormones, and inflammation were measured in 75 patients with PCOS and 77 healthy participants. All of the participants were divided into normal-weight (NW) and overweight/obese (OW) subgroups. Statistical analyses were performed with R studio. Results. PCOS patients manifested hyperandrogenism, increased luteinizing hormone/follicle-stimulating hormone (LH/FSH), and accumulated body fat and insulin resistance. Plasma DIAPH1 levels were significantly decreased in women with PCOS compared to control participants, and DIAPH1 levels were distinctly reduced in OW PCOS compared to OW control subjects (P<0.001). DIAPH1 levels correlated with fasting blood glucose (FBG), total cholesterol (TC), the homeostasis model assessment of β-cell function (HOMA-β), and LH/FSH in all participants (FBG: r=0.351, P<0.0001; TC: r=0.178, P=0.029; HOMA-β: r=−0.211, P=0.009; LH/FSH: r=−0.172, P=0.040). Multivariate logistic regression analysis revealed that plasma DIAPH1 levels were an independent risk factor for PCOS. A model containing DIAPH1, BMI, FBG, and testosterone was constructed to predict the risk of PCOS, with a sensitivity of 92.0% and a specificity of 80.9%. A nomogram was constructed to facilitate clinical diagnosis. Conclusions. These findings suggest the association of plasma DIAPH1 with glucose metabolism, insulin resistance, and sex hormones and support DIAPH1 as a potential predictive factor for PCOS. |
| format | Article |
| id | doaj-art-42185a75351a43eca14c094fc41759d8 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-42185a75351a43eca14c094fc41759d82025-02-03T01:07:12ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/9620423Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control StudyXing Li0Mingyu Liao1Jiaqing Shao2Weixin Li3Liu Shi4Dong Wang5Juan Ni6Qiuyue Shen7Fan Yang8Guiliang Peng9Ling Zhou10Yuling Zhang11Zheng Sun12Hongting Zheng13Min Long14Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of EndocrinologyNational Clinical Research Center of Kidney DiseasesDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of MedicineDepartment of EndocrinologyDepartment of EndocrinologyBackground. Diaphanous related formin 1 (DIAPH1) is a novel component of advanced glycation end product (AGE) signal transduction that was recently found to participate in diabetes-related disorders, obesity, and androgen hormones. We investigated whether plasma DIAPH1 levels were a potential prognostic predictor for polycystic ovary syndrome (PCOS). Methods. The levels of circulating plasma DIAPH1 and indicators of glucose, insulin, lipid metabolism, liver enzymes, kidney function, sex hormones, and inflammation were measured in 75 patients with PCOS and 77 healthy participants. All of the participants were divided into normal-weight (NW) and overweight/obese (OW) subgroups. Statistical analyses were performed with R studio. Results. PCOS patients manifested hyperandrogenism, increased luteinizing hormone/follicle-stimulating hormone (LH/FSH), and accumulated body fat and insulin resistance. Plasma DIAPH1 levels were significantly decreased in women with PCOS compared to control participants, and DIAPH1 levels were distinctly reduced in OW PCOS compared to OW control subjects (P<0.001). DIAPH1 levels correlated with fasting blood glucose (FBG), total cholesterol (TC), the homeostasis model assessment of β-cell function (HOMA-β), and LH/FSH in all participants (FBG: r=0.351, P<0.0001; TC: r=0.178, P=0.029; HOMA-β: r=−0.211, P=0.009; LH/FSH: r=−0.172, P=0.040). Multivariate logistic regression analysis revealed that plasma DIAPH1 levels were an independent risk factor for PCOS. A model containing DIAPH1, BMI, FBG, and testosterone was constructed to predict the risk of PCOS, with a sensitivity of 92.0% and a specificity of 80.9%. A nomogram was constructed to facilitate clinical diagnosis. Conclusions. These findings suggest the association of plasma DIAPH1 with glucose metabolism, insulin resistance, and sex hormones and support DIAPH1 as a potential predictive factor for PCOS.http://dx.doi.org/10.1155/2022/9620423 |
| spellingShingle | Xing Li Mingyu Liao Jiaqing Shao Weixin Li Liu Shi Dong Wang Juan Ni Qiuyue Shen Fan Yang Guiliang Peng Ling Zhou Yuling Zhang Zheng Sun Hongting Zheng Min Long Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study Mediators of Inflammation |
| title | Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study |
| title_full | Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study |
| title_fullStr | Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study |
| title_full_unstemmed | Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study |
| title_short | Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study |
| title_sort | plasma diaphanous related formin 1 levels are associated with altered glucose metabolism and insulin resistance in patients with polycystic ovary syndrome a case control study |
| url | http://dx.doi.org/10.1155/2022/9620423 |
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