Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report
Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serolog...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/568364 |
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| author | O. P. Arewa S. Nahirniak G. Clarke |
| author_facet | O. P. Arewa S. Nahirniak G. Clarke |
| author_sort | O. P. Arewa |
| collection | DOAJ |
| description | Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the most common antibody in cases reported. We report a case of posttransfusion purpura in an African American. The patient was negative for HPA-1a antibodies, but anti-HPA-1b was identified with a platelet phenotype of HPA-1a/HPA-1a. Although less common, HPA-1b antibody may be an important consideration in posttransfusion purpura diagnosed in patients of African descent. |
| format | Article |
| id | doaj-art-41fac32d170c44f0bb4ad7d78c3afb4c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-41fac32d170c44f0bb4ad7d78c3afb4c2025-02-03T01:09:43ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/568364568364Anti-HPA-1b Mediated Posttransfusion Purpura: A Case ReportO. P. Arewa0S. Nahirniak1G. Clarke2Department of Laboratory Medicine & Blood Bank, Arar Central Hospital, Arar, Saudi ArabiaDepartment of Laboratory Medicine & Pathology, University of Alberta Hospital, Edmonton, AB, CanadaDepartment of Laboratory Medicine & Pathology, University of Alberta Hospital, Edmonton, AB, CanadaPosttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the most common antibody in cases reported. We report a case of posttransfusion purpura in an African American. The patient was negative for HPA-1a antibodies, but anti-HPA-1b was identified with a platelet phenotype of HPA-1a/HPA-1a. Although less common, HPA-1b antibody may be an important consideration in posttransfusion purpura diagnosed in patients of African descent.http://dx.doi.org/10.1155/2013/568364 |
| spellingShingle | O. P. Arewa S. Nahirniak G. Clarke Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report Case Reports in Medicine |
| title | Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report |
| title_full | Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report |
| title_fullStr | Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report |
| title_full_unstemmed | Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report |
| title_short | Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report |
| title_sort | anti hpa 1b mediated posttransfusion purpura a case report |
| url | http://dx.doi.org/10.1155/2013/568364 |
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