Leukocyte migration in experimental inflammatory bowel disease
Emigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. The influx of n...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791776 |
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| author | E. P. Van Rees M. J. H. J. Palmen F. R. W. Van De Goot B. A. Macher L. A. Dieleman |
| author_facet | E. P. Van Rees M. J. H. J. Palmen F. R. W. Van De Goot B. A. Macher L. A. Dieleman |
| author_sort | E. P. Van Rees |
| collection | DOAJ |
| description | Emigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. The influx of neutrophils, monocytes and lymphocytes into inflamed tissue is important in the pathogenesis of chronic inflammatory bowel disease. The importance of each of these groups of adhesion molecules in chronic inflammatory bowel disease, either in human disease or in animal models, will be discussed below. Furthermore, the possibilities of blocking these different steps in the process of leukocyte extravasation in an attempt to prevent further tissue damage, will be taken into account. |
| format | Article |
| id | doaj-art-41f5851fd00740b6b6d965e7c76f2e8a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-41f5851fd00740b6b6d965e7c76f2e8a2025-02-03T01:10:24ZengWileyMediators of Inflammation0962-93511466-18611997-01-0162859310.1080/09629359791776Leukocyte migration in experimental inflammatory bowel diseaseE. P. Van Rees0M. J. H. J. Palmen1F. R. W. Van De Goot2B. A. Macher3L. A. Dieleman4Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam 1081 BT, The NetherlandsDepartment of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam 1081 BT, The NetherlandsDepartment of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam 1081 BT, The NetherlandsDepartment of Chemistry and Biochemistry, San Francisco State University, San Francisco, USADivision of Digestive Disease and Nutrition, University of North Carolina School of Medicine, Chapel Hill, NC, USAEmigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. The influx of neutrophils, monocytes and lymphocytes into inflamed tissue is important in the pathogenesis of chronic inflammatory bowel disease. The importance of each of these groups of adhesion molecules in chronic inflammatory bowel disease, either in human disease or in animal models, will be discussed below. Furthermore, the possibilities of blocking these different steps in the process of leukocyte extravasation in an attempt to prevent further tissue damage, will be taken into account.http://dx.doi.org/10.1080/09629359791776 |
| spellingShingle | E. P. Van Rees M. J. H. J. Palmen F. R. W. Van De Goot B. A. Macher L. A. Dieleman Leukocyte migration in experimental inflammatory bowel disease Mediators of Inflammation |
| title | Leukocyte migration in experimental inflammatory bowel disease |
| title_full | Leukocyte migration in experimental inflammatory bowel disease |
| title_fullStr | Leukocyte migration in experimental inflammatory bowel disease |
| title_full_unstemmed | Leukocyte migration in experimental inflammatory bowel disease |
| title_short | Leukocyte migration in experimental inflammatory bowel disease |
| title_sort | leukocyte migration in experimental inflammatory bowel disease |
| url | http://dx.doi.org/10.1080/09629359791776 |
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