Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study

Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study

Abstract Background Dysfunctional basal forebrain (BF) connectivity contributes to primary insomnia (PI). This study investigated whether transcutaneous auricular vagus nerve stimulation (taVNS) modulates BF functional connectivity (FC) in patients with PI and whether baseline FC predicts taVNS trea...

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Bibliographic Details
Main Authors: Meng Qi, Yiting Huang, Runru Mai, Zhaoxian Yan, Biyun Xu, Bo Liu, Yue Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Transcutaneous auricular vagus nerve stimulation
Treatment efficacy prediction
Primary insomnia
Functional connectivity of basal forebrain
Online Access:https://doi.org/10.1186/s12916-025-04126-7
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https://doi.org/10.1186/s12916-025-04126-7

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