Textbook outcome in ovarian cancer and its impact on survival: comparative study
Abstract Introduction Patients who achieve the textbook outcome (TO) present an uneventful postoperative course. Obtaining TO has also been related to better survival in oncological patients. Information about TO in patients with peritoneal carcinomatosis from ovarian cancer who undergo surgery is v...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03686-5 |
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| author | Silvia Carbonell-Morote Alvaro Arjona-Sánchez Pedro Antonio Cascales-Campos Alida González-Gil Gonzalo Gomez-Dueñas Elena Gil-Gómez Iban Caravaca-García Veronica Aranaz Francisco Javier Lacueva José Manuel Ramia |
| author_facet | Silvia Carbonell-Morote Alvaro Arjona-Sánchez Pedro Antonio Cascales-Campos Alida González-Gil Gonzalo Gomez-Dueñas Elena Gil-Gómez Iban Caravaca-García Veronica Aranaz Francisco Javier Lacueva José Manuel Ramia |
| author_sort | Silvia Carbonell-Morote |
| collection | DOAJ |
| description | Abstract Introduction Patients who achieve the textbook outcome (TO) present an uneventful postoperative course. Obtaining TO has also been related to better survival in oncological patients. Information about TO in patients with peritoneal carcinomatosis from ovarian cancer who undergo surgery is very scarce. Our objective was investigate TO in patients with carcinomatosis of ovarian origin who underwent interval surgery with or without HIPEC (TOOC) and its impact on survival. Methods A multicenter study was performed between 2010 and 2015. Inclusion criteria were > 18 years old, with ovarian cancer and peritoneal carcinomatosis, who underwent scheduled surgery after response to neoadjuvant therapy. The criteria to establish TOOC were no major complications, no mortality, non-prolonged stay (p75:10 days), complete cytoreduction (CC-0), and no readmission. Results 365 patients were included, and TOOC was achieved in 204 (55.9%) patients. CC-0 cytoreduction was obtained in 312(85.5%). 7 patients (1.9%) died. 71 (19.5%) presented major complications (≥ IIIa). The readmission rate was 9.3%, and 24.9% of the patients presented a prolonged stay. The parameter with most significant negative impact on achieving TOOC was length of stay. Multivariate analysis confirmed postsurgical PCI, age, HIPEC, and time of surgery in minutes as an independent factor of TOOC. Survival analysis showed that patients who achieved TOOC had better overall survival (41 months (24.5– 67) versus 27 months (14-48.2) (p < 0.0001). Conclusion TO is an easy and valuable management tool for evaluating and comparing results obtained at different centers after surgery for peritoneal carcinomatosis of locally advanced ovarian cancer. Achieving TOOC benefits overall survival. |
| format | Article |
| id | doaj-art-41cab93e208e432c94597932e0e9c040 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-41cab93e208e432c94597932e0e9c0402025-02-02T12:27:30ZengBMCWorld Journal of Surgical Oncology1477-78192025-02-012311910.1186/s12957-025-03686-5Textbook outcome in ovarian cancer and its impact on survival: comparative studySilvia Carbonell-Morote0Alvaro Arjona-Sánchez1Pedro Antonio Cascales-Campos2Alida González-Gil3Gonzalo Gomez-Dueñas4Elena Gil-Gómez5Iban Caravaca-García6Veronica Aranaz7Francisco Javier Lacueva8José Manuel Ramia9Universidad Miguel HernándezHospital Universitario Reina Sofía CórdobaPeritoneal Carcinomatosis unit Department of Surgery, Hospital Universitario Virgen De la ArrixacaPeritoneal Carcinomatosis unit Department of Surgery, Hospital Universitario Virgen De la ArrixacaHospital Universitario Reina Sofía CórdobaPeritoneal Carcinomatosis unit Department of Surgery, Hospital Universitario Virgen De la ArrixacaHospital General Universitario de ElcheHospital General Universitario de ElcheUniversidad Miguel HernándezUniversidad Miguel HernándezAbstract Introduction Patients who achieve the textbook outcome (TO) present an uneventful postoperative course. Obtaining TO has also been related to better survival in oncological patients. Information about TO in patients with peritoneal carcinomatosis from ovarian cancer who undergo surgery is very scarce. Our objective was investigate TO in patients with carcinomatosis of ovarian origin who underwent interval surgery with or without HIPEC (TOOC) and its impact on survival. Methods A multicenter study was performed between 2010 and 2015. Inclusion criteria were > 18 years old, with ovarian cancer and peritoneal carcinomatosis, who underwent scheduled surgery after response to neoadjuvant therapy. The criteria to establish TOOC were no major complications, no mortality, non-prolonged stay (p75:10 days), complete cytoreduction (CC-0), and no readmission. Results 365 patients were included, and TOOC was achieved in 204 (55.9%) patients. CC-0 cytoreduction was obtained in 312(85.5%). 7 patients (1.9%) died. 71 (19.5%) presented major complications (≥ IIIa). The readmission rate was 9.3%, and 24.9% of the patients presented a prolonged stay. The parameter with most significant negative impact on achieving TOOC was length of stay. Multivariate analysis confirmed postsurgical PCI, age, HIPEC, and time of surgery in minutes as an independent factor of TOOC. Survival analysis showed that patients who achieved TOOC had better overall survival (41 months (24.5– 67) versus 27 months (14-48.2) (p < 0.0001). Conclusion TO is an easy and valuable management tool for evaluating and comparing results obtained at different centers after surgery for peritoneal carcinomatosis of locally advanced ovarian cancer. Achieving TOOC benefits overall survival.https://doi.org/10.1186/s12957-025-03686-5Textbook outcomeBenchmarkingOvarian cancerCarcinomatosisHIPEC |
| spellingShingle | Silvia Carbonell-Morote Alvaro Arjona-Sánchez Pedro Antonio Cascales-Campos Alida González-Gil Gonzalo Gomez-Dueñas Elena Gil-Gómez Iban Caravaca-García Veronica Aranaz Francisco Javier Lacueva José Manuel Ramia Textbook outcome in ovarian cancer and its impact on survival: comparative study World Journal of Surgical Oncology Textbook outcome Benchmarking Ovarian cancer Carcinomatosis HIPEC |
| title | Textbook outcome in ovarian cancer and its impact on survival: comparative study |
| title_full | Textbook outcome in ovarian cancer and its impact on survival: comparative study |
| title_fullStr | Textbook outcome in ovarian cancer and its impact on survival: comparative study |
| title_full_unstemmed | Textbook outcome in ovarian cancer and its impact on survival: comparative study |
| title_short | Textbook outcome in ovarian cancer and its impact on survival: comparative study |
| title_sort | textbook outcome in ovarian cancer and its impact on survival comparative study |
| topic | Textbook outcome Benchmarking Ovarian cancer Carcinomatosis HIPEC |
| url | https://doi.org/10.1186/s12957-025-03686-5 |
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