Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?
Partial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures. This is a time-critical step due to the critical ischemia period of renal tissue. Prolonged renal ischemia may lead to ir...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2018/9852791 |
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| author | Kapil Sethi Kenny Rao Damien Bolton Oneel Patel Joseph Ischia |
| author_facet | Kapil Sethi Kenny Rao Damien Bolton Oneel Patel Joseph Ischia |
| author_sort | Kapil Sethi |
| collection | DOAJ |
| description | Partial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures. This is a time-critical step due to the critical ischemia period of renal tissue. Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI). A key mechanism in IRI prevention appears to be the upregulation of an intracellular transcription protein, Hypoxia-Inducible Factor (HIF). HIF mediates metabolic adaptation, angiogenesis, erythropoiesis, cell growth, survival, and apoptosis. Upregulating HIF-1α via ischemic preconditioning (IPC) or drugs that simulate hypoxia (hypoxia-mimetics) has been investigated as a method to reduce IRI. While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials. The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury. |
| format | Article |
| id | doaj-art-41c7d2decde647fea8a417daa30525ec |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-41c7d2decde647fea8a417daa30525ec2025-02-03T05:51:56ZengWileyInternational Journal of Cell Biology1687-88761687-88842018-01-01201810.1155/2018/98527919852791Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?Kapil Sethi0Kenny Rao1Damien Bolton2Oneel Patel3Joseph Ischia4Department of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, AustraliaDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, AustraliaDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, AustraliaDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, AustraliaDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, AustraliaPartial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures. This is a time-critical step due to the critical ischemia period of renal tissue. Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI). A key mechanism in IRI prevention appears to be the upregulation of an intracellular transcription protein, Hypoxia-Inducible Factor (HIF). HIF mediates metabolic adaptation, angiogenesis, erythropoiesis, cell growth, survival, and apoptosis. Upregulating HIF-1α via ischemic preconditioning (IPC) or drugs that simulate hypoxia (hypoxia-mimetics) has been investigated as a method to reduce IRI. While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials. The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury.http://dx.doi.org/10.1155/2018/9852791 |
| spellingShingle | Kapil Sethi Kenny Rao Damien Bolton Oneel Patel Joseph Ischia Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? International Journal of Cell Biology |
| title | Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? |
| title_full | Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? |
| title_fullStr | Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? |
| title_full_unstemmed | Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? |
| title_short | Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? |
| title_sort | targeting hif 1α to prevent renal ischemia reperfusion injury does it work |
| url | http://dx.doi.org/10.1155/2018/9852791 |
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