Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems
Nucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, and drug development. Among various types of nucleic acids, RNA offers greater versatility compared to DNA due to its single-stranded stru...
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MDPI AG
2024-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/1/22 |
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| author | Yuxuan Liu Yaohui Ou Linlin Hou |
| author_facet | Yuxuan Liu Yaohui Ou Linlin Hou |
| author_sort | Yuxuan Liu |
| collection | DOAJ |
| description | Nucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, and drug development. Among various types of nucleic acids, RNA offers greater versatility compared to DNA due to its single-stranded structure, ability to directly encode proteins, and high modifiability for targeted therapeutic and regulatory applications. Despite its promising potential in biomedicine, RNA-based medicine still faces several challenges. Notably, one of the most significant technical hurdles is achieving efficient and targeted RNA delivery while minimizing immune responses. Various strategies have been developed for RNA delivery, including viral vectors, virus-like particles (VLPs), lipid nanoparticles (LNPs), and extracellular vesicles (EVs). In this review, we explore the applications of these delivery methods, highlight their advantages and limitations, and discuss recent research advancements, providing insights for the future of RNA-based therapeutics. |
| format | Article |
| id | doaj-art-41c78091cfdd416a9f36b29852138dd4 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-41c78091cfdd416a9f36b29852138dd42025-01-24T13:27:25ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-014712210.3390/cimb47010022Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery SystemsYuxuan Liu0Yaohui Ou1Linlin Hou2School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaNucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, and drug development. Among various types of nucleic acids, RNA offers greater versatility compared to DNA due to its single-stranded structure, ability to directly encode proteins, and high modifiability for targeted therapeutic and regulatory applications. Despite its promising potential in biomedicine, RNA-based medicine still faces several challenges. Notably, one of the most significant technical hurdles is achieving efficient and targeted RNA delivery while minimizing immune responses. Various strategies have been developed for RNA delivery, including viral vectors, virus-like particles (VLPs), lipid nanoparticles (LNPs), and extracellular vesicles (EVs). In this review, we explore the applications of these delivery methods, highlight their advantages and limitations, and discuss recent research advancements, providing insights for the future of RNA-based therapeutics.https://www.mdpi.com/1467-3045/47/1/22RNA-based therapeuticsRNA delivery systemsviral vectorsvirus-like particles (VLPs)lipid nanoparticles (LNPs)extracellular vesicles (EVs) |
| spellingShingle | Yuxuan Liu Yaohui Ou Linlin Hou Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems Current Issues in Molecular Biology RNA-based therapeutics RNA delivery systems viral vectors virus-like particles (VLPs) lipid nanoparticles (LNPs) extracellular vesicles (EVs) |
| title | Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems |
| title_full | Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems |
| title_fullStr | Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems |
| title_full_unstemmed | Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems |
| title_short | Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems |
| title_sort | advances in rna based therapeutics challenges and innovations in rna delivery systems |
| topic | RNA-based therapeutics RNA delivery systems viral vectors virus-like particles (VLPs) lipid nanoparticles (LNPs) extracellular vesicles (EVs) |
| url | https://www.mdpi.com/1467-3045/47/1/22 |
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