Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications
The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tunin...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/1/e101374.full |
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| author | Yan Zhang Jin Liu Junzhe Cheng Hongkun Hu Yumeng Ju Mi Wang Bangshan Liu |
| author_facet | Yan Zhang Jin Liu Junzhe Cheng Hongkun Hu Yumeng Ju Mi Wang Bangshan Liu |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites of the gut microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component of the microbiota-gut-brain axis in depression. In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. Concluding remarks on the biological mechanisms related to gut microbiota will hopefully address the clinical value of microbiota-related treatments for depression. |
| format | Article |
| id | doaj-art-41be07fd54d54b5d8606c24c1c15b74d |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-41be07fd54d54b5d8606c24c1c15b74d2025-01-29T16:15:13ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-02-0137110.1136/gpsych-2023-101374Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applicationsYan Zhang0Jin Liu1Junzhe Cheng2Hongkun Hu3Yumeng Ju4Mi Wang5Bangshan Liu61 School of Public Health, Chongqing Medical University, Chongqing, China3 Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, Hunan, China1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, Second Xiangya Hospital of Central South University, Changsha, Hunan, China2 Clinical Medicine Eight-Year Program, Xiangya School of Medicine, Central South University, Changsha, Hunan, China1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China4 Department of Mental Health Center, Xiangya Hospital of Central South University, Changsha, Hunan, China1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaThe gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites of the gut microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component of the microbiota-gut-brain axis in depression. In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. Concluding remarks on the biological mechanisms related to gut microbiota will hopefully address the clinical value of microbiota-related treatments for depression.https://gpsych.bmj.com/content/37/1/e101374.full |
| spellingShingle | Yan Zhang Jin Liu Junzhe Cheng Hongkun Hu Yumeng Ju Mi Wang Bangshan Liu Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications General Psychiatry |
| title | Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications |
| title_full | Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications |
| title_fullStr | Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications |
| title_full_unstemmed | Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications |
| title_short | Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications |
| title_sort | gut microbiota derived short chain fatty acids and depression deep insight into biological mechanisms and potential applications |
| url | https://gpsych.bmj.com/content/37/1/e101374.full |
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