Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-12-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2017-0031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569651892060160 |
|---|---|
| author | Stolarczyk Mariusz Apola Anna Maślanka Anna Kwiecień Anna Opoka Włodzimierz |
| author_facet | Stolarczyk Mariusz Apola Anna Maślanka Anna Kwiecień Anna Opoka Włodzimierz |
| author_sort | Stolarczyk Mariusz |
| collection | DOAJ |
| description | Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL-1 for valsartan, 8.16-28.56 mg mL-1 f or fluvastatin, 14.40-39.90 mg mL-1 for atorvastatin and 9.60-48.00 mg mL-1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations. |
| format | Article |
| id | doaj-art-41bb690d2f114122b74945c567ff21a0 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-41bb690d2f114122b74945c567ff21a02025-02-02T19:57:23ZengSciendoActa Pharmaceutica1846-95582017-12-0167446347810.1515/acph-2017-0031acph-2017-0031Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixturesStolarczyk Mariusz0Apola Anna1Maślanka Anna2Kwiecień Anna3Opoka Włodzimierz4Department of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, PolandDepartment of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, PolandDepartment of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, PolandDepartment of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, PolandDepartment of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, PolandApplicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL-1 for valsartan, 8.16-28.56 mg mL-1 f or fluvastatin, 14.40-39.90 mg mL-1 for atorvastatin and 9.60-48.00 mg mL-1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.https://doi.org/10.1515/acph-2017-0031valsartanatorvastatinfluvastatinpravastatinderivative spectrophotometry |
| spellingShingle | Stolarczyk Mariusz Apola Anna Maślanka Anna Kwiecień Anna Opoka Włodzimierz Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures Acta Pharmaceutica valsartan atorvastatin fluvastatin pravastatin derivative spectrophotometry |
| title | Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| title_full | Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| title_fullStr | Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| title_full_unstemmed | Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| title_short | Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| title_sort | spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures |
| topic | valsartan atorvastatin fluvastatin pravastatin derivative spectrophotometry |
| url | https://doi.org/10.1515/acph-2017-0031 |
| work_keys_str_mv | AT stolarczykmariusz spectrophotometricmethodforsimultaneousdeterminationofvalsartanandsubstancesfromthegroupofstatinsinbinarymixtures AT apolaanna spectrophotometricmethodforsimultaneousdeterminationofvalsartanandsubstancesfromthegroupofstatinsinbinarymixtures AT maslankaanna spectrophotometricmethodforsimultaneousdeterminationofvalsartanandsubstancesfromthegroupofstatinsinbinarymixtures AT kwiecienanna spectrophotometricmethodforsimultaneousdeterminationofvalsartanandsubstancesfromthegroupofstatinsinbinarymixtures AT opokawłodzimierz spectrophotometricmethodforsimultaneousdeterminationofvalsartanandsubstancesfromthegroupofstatinsinbinarymixtures |