Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells
We have studied the effect of human recombinant tumour necrosis factor-α (TNF-α) on gene expression and production of endothelin-1 in cultured bovine aortic endothelial cells. TNF-α (10 and 100 ng ml−1) increased in a time dependent manner the preproendothelin-1 mRNA levels in respect to unstimulate...
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Main Authors: | Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi |
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Format: | Article |
Language: | English |
Published: |
Wiley
1992-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/S0962935192000401 |
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