Relationship between functional structures and horizontal connections in macaque inferior temporal cortex
Abstract Horizontal connections in anterior inferior temporal cortex (ITC) are thought to play an important role in object recognition by integrating information across spatially separated functional columns, but their functional organization remains unclear. Using a combination of optical imaging,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87517-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571716347363328 |
|---|---|
| author | Danling Hu Takayuki Sato Kathleen S. Rockland Manabu Tanifuji Hisashi Tanigawa |
| author_facet | Danling Hu Takayuki Sato Kathleen S. Rockland Manabu Tanifuji Hisashi Tanigawa |
| author_sort | Danling Hu |
| collection | DOAJ |
| description | Abstract Horizontal connections in anterior inferior temporal cortex (ITC) are thought to play an important role in object recognition by integrating information across spatially separated functional columns, but their functional organization remains unclear. Using a combination of optical imaging, electrophysiological recording, and anatomical tracing, we investigated the relationship between stimulus-response maps and patterns of horizontal axon terminals in the macaque ITC. In contrast to the “like-to-like” connectivity observed in the early visual cortex, we found that horizontal axons in ITC do not preferentially connect sites with similar object selectivity. While some axon terminal patches shared responsiveness to specific visual features with the injection site, many connected to regions with different selectivity. Our results suggest that horizontal connections in anterior ITC exhibit diverse functional connectivity, potentially supporting flexible integration of visual information for advanced object recognition processes. |
| format | Article |
| id | doaj-art-41aa7757c12642478f1b0fbc28ce18cd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-41aa7757c12642478f1b0fbc28ce18cd2025-02-02T12:20:42ZengNature PortfolioScientific Reports2045-23222025-01-0115111510.1038/s41598-025-87517-3Relationship between functional structures and horizontal connections in macaque inferior temporal cortexDanling Hu0Takayuki Sato1Kathleen S. Rockland2Manabu Tanifuji3Hisashi Tanigawa4Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang UniversityLaboratory for Integrative Neural Systems, RIKEN Center for Brain ScienceDepartment of Anatomy and Neurobiology, Chobanian & Avedisian School of Medicine, Boston UniversityLaboratory for Integrative Neural Systems, RIKEN Center for Brain ScienceDepartment of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang UniversityAbstract Horizontal connections in anterior inferior temporal cortex (ITC) are thought to play an important role in object recognition by integrating information across spatially separated functional columns, but their functional organization remains unclear. Using a combination of optical imaging, electrophysiological recording, and anatomical tracing, we investigated the relationship between stimulus-response maps and patterns of horizontal axon terminals in the macaque ITC. In contrast to the “like-to-like” connectivity observed in the early visual cortex, we found that horizontal axons in ITC do not preferentially connect sites with similar object selectivity. While some axon terminal patches shared responsiveness to specific visual features with the injection site, many connected to regions with different selectivity. Our results suggest that horizontal connections in anterior ITC exhibit diverse functional connectivity, potentially supporting flexible integration of visual information for advanced object recognition processes.https://doi.org/10.1038/s41598-025-87517-3Intrinsic signal optical imagingAnterograde tracerMonkeyNon-human primateIntrinsic connections |
| spellingShingle | Danling Hu Takayuki Sato Kathleen S. Rockland Manabu Tanifuji Hisashi Tanigawa Relationship between functional structures and horizontal connections in macaque inferior temporal cortex Scientific Reports Intrinsic signal optical imaging Anterograde tracer Monkey Non-human primate Intrinsic connections |
| title | Relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| title_full | Relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| title_fullStr | Relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| title_full_unstemmed | Relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| title_short | Relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| title_sort | relationship between functional structures and horizontal connections in macaque inferior temporal cortex |
| topic | Intrinsic signal optical imaging Anterograde tracer Monkey Non-human primate Intrinsic connections |
| url | https://doi.org/10.1038/s41598-025-87517-3 |
| work_keys_str_mv | AT danlinghu relationshipbetweenfunctionalstructuresandhorizontalconnectionsinmacaqueinferiortemporalcortex AT takayukisato relationshipbetweenfunctionalstructuresandhorizontalconnectionsinmacaqueinferiortemporalcortex AT kathleensrockland relationshipbetweenfunctionalstructuresandhorizontalconnectionsinmacaqueinferiortemporalcortex AT manabutanifuji relationshipbetweenfunctionalstructuresandhorizontalconnectionsinmacaqueinferiortemporalcortex AT hisashitanigawa relationshipbetweenfunctionalstructuresandhorizontalconnectionsinmacaqueinferiortemporalcortex |