Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma
Background. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. Aim. To e...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/9015453 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552632705613824 |
|---|---|
| author | Taewoo Yang Yegyun Choi Jae Won Joh Steve K. Cho Dae-Shick Kim Sung-Gyoo Park |
| author_facet | Taewoo Yang Yegyun Choi Jae Won Joh Steve K. Cho Dae-Shick Kim Sung-Gyoo Park |
| author_sort | Taewoo Yang |
| collection | DOAJ |
| description | Background. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. Aim. To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. Methods. Surgically resected tumors from 199 HCC patients were analyzed for p21, p53, p53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry. Results. Stratifying by the expression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients with HCC. Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-P–negative had significantly worse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-P–positive. Conclusions. P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC. |
| format | Article |
| id | doaj-art-41a38ee0b95e44f98f892d5ade5c0eb1 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-41a38ee0b95e44f98f892d5ade5c0eb12025-02-03T05:58:12ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/90154539015453Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular CarcinomaTaewoo Yang0Yegyun Choi1Jae Won Joh2Steve K. Cho3Dae-Shick Kim4Sung-Gyoo Park5School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of KoreaSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of KoreaDepartment of Surgery, Samsung Medical Center, Seoul 06351, Republic of KoreaSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of KoreaDepartment of Pathology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of KoreaBackground. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. Aim. To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. Methods. Surgically resected tumors from 199 HCC patients were analyzed for p21, p53, p53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry. Results. Stratifying by the expression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients with HCC. Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-P–negative had significantly worse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-P–positive. Conclusions. P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC.http://dx.doi.org/10.1155/2019/9015453 |
| spellingShingle | Taewoo Yang Yegyun Choi Jae Won Joh Steve K. Cho Dae-Shick Kim Sung-Gyoo Park Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma Canadian Journal of Gastroenterology and Hepatology |
| title | Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma |
| title_full | Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma |
| title_fullStr | Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma |
| title_short | Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma |
| title_sort | phosphorylation of p53 serine 15 is a predictor of survival for patients with hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2019/9015453 |
| work_keys_str_mv | AT taewooyang phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma AT yegyunchoi phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma AT jaewonjoh phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma AT stevekcho phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma AT daeshickkim phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma AT sunggyoopark phosphorylationofp53serine15isapredictorofsurvivalforpatientswithhepatocellularcarcinoma |