An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma
ABSTRACT Background Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol‐related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and reversible pathologies to hepatocellular car...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70524 |
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| author | Anoïsia Courtois Sophie Gérard Damien Esparteiro Eric Nguyen‐Khac Ingrid Marcq Grégory Fouquet |
| author_facet | Anoïsia Courtois Sophie Gérard Damien Esparteiro Eric Nguyen‐Khac Ingrid Marcq Grégory Fouquet |
| author_sort | Anoïsia Courtois |
| collection | DOAJ |
| description | ABSTRACT Background Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol‐related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and reversible pathologies to hepatocellular carcinoma (HCC), a highly prevalent and deadly liver cancer. Indeed, alcohol consumption is one of the main worldwide etiologies of HCC. However, the impact of alcohol consumption on HCC pathophysiology and the associated mechanisms remains unclear. Thus, in vitro alcohol‐related HCC models are essential for addressing this issue and for assessing new molecular markers of this disease. In this review, we discuss the current in vitro models of alcohol‐related HCC. Our global overview demonstrates the lack of uniformity regarding HCC cell lines, alcohol concentration, and duration of alcohol exposure among existing models. Despite efforts to model alcohol exposure effectively that demonstrate enhancement of cancer cell transformation markers and HCC aggressiveness following, respectively, short‐term and long‐term alcohol exposure, current in vitro models possess numerous limitations. Aim This review highlights future challenges in the development of more integrated and representative models of the complex pathophysiology of alcohol‐related HCC. |
| format | Article |
| id | doaj-art-419f2dc3c1454d07aa7abde403fac4c8 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-419f2dc3c1454d07aa7abde403fac4c82025-01-24T08:46:07ZengWileyCancer Medicine2045-76342025-01-01142n/an/a10.1002/cam4.70524An Overview of In Vitro Models of Alcohol‐Related Hepatocellular CarcinomaAnoïsia Courtois0Sophie Gérard1Damien Esparteiro2Eric Nguyen‐Khac3Ingrid Marcq4Grégory Fouquet5GRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceGRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceGRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceGRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceGRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceGRAP INSERM U1247, Curs Université Picardie Jules Verne Amiens FranceABSTRACT Background Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol‐related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and reversible pathologies to hepatocellular carcinoma (HCC), a highly prevalent and deadly liver cancer. Indeed, alcohol consumption is one of the main worldwide etiologies of HCC. However, the impact of alcohol consumption on HCC pathophysiology and the associated mechanisms remains unclear. Thus, in vitro alcohol‐related HCC models are essential for addressing this issue and for assessing new molecular markers of this disease. In this review, we discuss the current in vitro models of alcohol‐related HCC. Our global overview demonstrates the lack of uniformity regarding HCC cell lines, alcohol concentration, and duration of alcohol exposure among existing models. Despite efforts to model alcohol exposure effectively that demonstrate enhancement of cancer cell transformation markers and HCC aggressiveness following, respectively, short‐term and long‐term alcohol exposure, current in vitro models possess numerous limitations. Aim This review highlights future challenges in the development of more integrated and representative models of the complex pathophysiology of alcohol‐related HCC.https://doi.org/10.1002/cam4.70524alcoholhepatocellular carcinomain vitro models |
| spellingShingle | Anoïsia Courtois Sophie Gérard Damien Esparteiro Eric Nguyen‐Khac Ingrid Marcq Grégory Fouquet An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma Cancer Medicine alcohol hepatocellular carcinoma in vitro models |
| title | An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma |
| title_full | An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma |
| title_fullStr | An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma |
| title_full_unstemmed | An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma |
| title_short | An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma |
| title_sort | overview of in vitro models of alcohol related hepatocellular carcinoma |
| topic | alcohol hepatocellular carcinoma in vitro models |
| url | https://doi.org/10.1002/cam4.70524 |
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