Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers
Objectives. To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers. Methods. The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO2 nanoparticles were added to the composite resin as antibac...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2022/3912290 |
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| author | Eldho Jijy Varghese Dhanasekaran Sihivahanan Kondas Vijay Venkatesh |
| author_facet | Eldho Jijy Varghese Dhanasekaran Sihivahanan Kondas Vijay Venkatesh |
| author_sort | Eldho Jijy Varghese |
| collection | DOAJ |
| description | Objectives. To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers. Methods. The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO2 nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against Streptococcus mutans, Streptococcus mitis, Streptococcus aureus, and Lactobacillus spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control. Results. The experimental dental composite demonstrated 99.503% efficacy against Streptococcus mutans, 99.441% efficacy against Streptococcus mitis, 99.416% efficacy against Streptococcus aureus, and 99.233% efficacy against Lactobacillus spp. Conclusion. Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. Clinical Significance. Previous studies attempted adding CeO2 nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations. |
| format | Article |
| id | doaj-art-4195435011ef43529077985b4e55480a |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4195435011ef43529077985b4e55480a2025-02-03T07:24:16ZengWileyInternational Journal of Biomaterials1687-87952022-01-01202210.1155/2022/3912290Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide FillersEldho Jijy Varghese0Dhanasekaran Sihivahanan1Kondas Vijay Venkatesh2Department of Conservative Dentistry and EndodonticsDepartment of Conservative Dentistry and EndodonticsDepartment of Conservative Dentistry and EndodonticsObjectives. To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers. Methods. The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO2 nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against Streptococcus mutans, Streptococcus mitis, Streptococcus aureus, and Lactobacillus spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control. Results. The experimental dental composite demonstrated 99.503% efficacy against Streptococcus mutans, 99.441% efficacy against Streptococcus mitis, 99.416% efficacy against Streptococcus aureus, and 99.233% efficacy against Lactobacillus spp. Conclusion. Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. Clinical Significance. Previous studies attempted adding CeO2 nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations.http://dx.doi.org/10.1155/2022/3912290 |
| spellingShingle | Eldho Jijy Varghese Dhanasekaran Sihivahanan Kondas Vijay Venkatesh Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers International Journal of Biomaterials |
| title | Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers |
| title_full | Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers |
| title_fullStr | Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers |
| title_full_unstemmed | Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers |
| title_short | Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers |
| title_sort | development of novel antimicrobial dental composite resin with nano cerium oxide fillers |
| url | http://dx.doi.org/10.1155/2022/3912290 |
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