Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice
Background. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care. Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients...
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| Format: | Article |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/758397 |
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| author | Bhupesh Dewan Aarthi Balasubramanian |
| author_facet | Bhupesh Dewan Aarthi Balasubramanian |
| author_sort | Bhupesh Dewan |
| collection | DOAJ |
| description | Background. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care.
Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients were randomized to Troxipide (100 mg tid) or Ranitidine (150 mg bid) for a period of four weeks. The severity of the signs of endoscopic gastritis at baseline and week 4 using a four-point scale and the subjective symptom severity at baseline and week 2 & week 4 using a Visual analog scale (VAS) were documented. Results. Troxipide was found to be superior to Ranitidine for both, the complete resolution and improvement of endoscopic gastritis. Higher proportion of patients showed complete healing of erosions (88.14%), oozing (96.77%), and edema (93.88%) with Troxipide as compared to Ranitidine (𝑃<.01). Patients receiving Troxipide also showed a greater improvement in the VAS scores for abdominal pain, bloating, and heartburn (𝑃<.01). Both the drugs were found to be well tolerated. Conclusion. In patients with endoscopic gastritis, Troxipide, with its superior rate of improvement, resolution of signs, and subjective clinical symptoms, can be considered as an alternative to the commonly used antisecretory agents. |
| format | Article |
| id | doaj-art-418ac3d34e8f4ef3b485eab6f09facfd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-418ac3d34e8f4ef3b485eab6f09facfd2025-02-03T05:57:42ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/758397758397Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General PracticeBhupesh Dewan0Aarthi Balasubramanian1Medical Services Department, Zuventus Healthcare Ltd, 5119, ‘D’ Wing, Oberoi Garden Estates, Chandivali, Mumbai 400072, IndiaMedical Services Department, Zuventus Healthcare Ltd, 5119, ‘D’ Wing, Oberoi Garden Estates, Chandivali, Mumbai 400072, IndiaBackground. A trial of empirical acid-suppressive therapy is the usual practice for most patients with symptoms of gastritis in primary care. Aim. To assess the relative efficacy of Troxipide and Ranitidine in patients with endoscopic gastritis over a four-week period. Methods. In all, 142 patients were randomized to Troxipide (100 mg tid) or Ranitidine (150 mg bid) for a period of four weeks. The severity of the signs of endoscopic gastritis at baseline and week 4 using a four-point scale and the subjective symptom severity at baseline and week 2 & week 4 using a Visual analog scale (VAS) were documented. Results. Troxipide was found to be superior to Ranitidine for both, the complete resolution and improvement of endoscopic gastritis. Higher proportion of patients showed complete healing of erosions (88.14%), oozing (96.77%), and edema (93.88%) with Troxipide as compared to Ranitidine (𝑃<.01). Patients receiving Troxipide also showed a greater improvement in the VAS scores for abdominal pain, bloating, and heartburn (𝑃<.01). Both the drugs were found to be well tolerated. Conclusion. In patients with endoscopic gastritis, Troxipide, with its superior rate of improvement, resolution of signs, and subjective clinical symptoms, can be considered as an alternative to the commonly used antisecretory agents.http://dx.doi.org/10.1155/2010/758397 |
| spellingShingle | Bhupesh Dewan Aarthi Balasubramanian Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice Gastroenterology Research and Practice |
| title | Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice |
| title_full | Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice |
| title_fullStr | Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice |
| title_full_unstemmed | Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice |
| title_short | Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice |
| title_sort | troxipide in the management of gastritis a randomized comparative trial in general practice |
| url | http://dx.doi.org/10.1155/2010/758397 |
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