Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis
Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right tho...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/545603 |
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| author | Catarina Araújo Cristina Resende Francisco Pardal Celeste Brito |
| author_facet | Catarina Araújo Cristina Resende Francisco Pardal Celeste Brito |
| author_sort | Catarina Araújo |
| collection | DOAJ |
| description | Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient. |
| format | Article |
| id | doaj-art-41618765d7a84a809f42d1af1f7e19e9 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-41618765d7a84a809f42d1af1f7e19e92025-02-03T05:52:14ZengWileyCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/545603545603Giant Congenital Melanocytic Nevi and Neurocutaneous MelanosisCatarina Araújo0Cristina Resende1Francisco Pardal2Celeste Brito3Dermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, PortugalDermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, PortugalPathological Anatomy Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, PortugalDermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, PortugalIntroduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.http://dx.doi.org/10.1155/2015/545603 |
| spellingShingle | Catarina Araújo Cristina Resende Francisco Pardal Celeste Brito Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis Case Reports in Medicine |
| title | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
| title_full | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
| title_fullStr | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
| title_full_unstemmed | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
| title_short | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
| title_sort | giant congenital melanocytic nevi and neurocutaneous melanosis |
| url | http://dx.doi.org/10.1155/2015/545603 |
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