Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis
An association exists between nonalcoholic fatty liver disease (NAFLD) and growth hormone (GH). Patients with growth hormone deficiency (GHD) may be more susceptible to NAFLD. The prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) in GHD patients is currently unknown. Multiple databases wer...
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The Japan Endocrine Society
2023-10-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0157/_html/-char/en |
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| _version_ | 1832591692527566848 |
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| author | Tingting Kong Yunpeng Gu Lei Sun Run Zhou Jie Li Junping Shi |
| author_facet | Tingting Kong Yunpeng Gu Lei Sun Run Zhou Jie Li Junping Shi |
| author_sort | Tingting Kong |
| collection | DOAJ |
| description | An association exists between nonalcoholic fatty liver disease (NAFLD) and growth hormone (GH). Patients with growth hormone deficiency (GHD) may be more susceptible to NAFLD. The prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) in GHD patients is currently unknown. Multiple databases were searched for experiments related to NAFLD (or NASH) and GHD. Screening, quality evaluation and data extraction were carried out independently by two authors. Analyses used random or fixed effects models, including NAFLD prevalence, NASH prevalence, odds ratio (OR) and 95% confidence interval (CI). We included 10 studies with a total of 782 participants. The results showed that the prevalence of NAFLD in GHD patients was 51% (95% CI: 39–63). The risk of NAFLD in GHD patients was significantly higher than that in controls (age-, sex- or body mass index-matched, without GHD) (pooled OR = 4.27, 95% CI: 1.33–13.68%, p = 0.015). The prevalence of NASH in GHD patients was 18% (95% CI: 5–31). The prevalence of NAFLD in GHD patients is significantly higher than that in the general population, especially NASH. There is a need to develop targeted strategies for the early identification, prevention, or control of NAFLD/NASH in patients with GHD. |
| format | Article |
| id | doaj-art-415d2603c95f4de5948aecf294f10b1a |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-415d2603c95f4de5948aecf294f10b1a2025-01-22T06:19:20ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-10-01701095996710.1507/endocrj.EJ23-0157endocrjAssociation of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysisTingting Kong0Yunpeng Gu1Lei Sun2Run Zhou3Jie Li4Junping Shi5School of Nursing, Hangzhou Normal University, Zhejiang 310015, ChinaSchool of Public Health, Hangzhou Normal University, Zhejiang 310015, ChinaSchool of Clinical Medicine, Hangzhou Normal University, Zhejiang 310015, ChinaSchool of Nursing, Hangzhou Normal University, Zhejiang 310015, ChinaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu 210008, ChinaInstitute of Hepatology and Metabolic Diseases, Hangzhou Normal University, Zhejiang 310015, ChinaAn association exists between nonalcoholic fatty liver disease (NAFLD) and growth hormone (GH). Patients with growth hormone deficiency (GHD) may be more susceptible to NAFLD. The prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) in GHD patients is currently unknown. Multiple databases were searched for experiments related to NAFLD (or NASH) and GHD. Screening, quality evaluation and data extraction were carried out independently by two authors. Analyses used random or fixed effects models, including NAFLD prevalence, NASH prevalence, odds ratio (OR) and 95% confidence interval (CI). We included 10 studies with a total of 782 participants. The results showed that the prevalence of NAFLD in GHD patients was 51% (95% CI: 39–63). The risk of NAFLD in GHD patients was significantly higher than that in controls (age-, sex- or body mass index-matched, without GHD) (pooled OR = 4.27, 95% CI: 1.33–13.68%, p = 0.015). The prevalence of NASH in GHD patients was 18% (95% CI: 5–31). The prevalence of NAFLD in GHD patients is significantly higher than that in the general population, especially NASH. There is a need to develop targeted strategies for the early identification, prevention, or control of NAFLD/NASH in patients with GHD.https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0157/_html/-char/ennonalcoholic fatty liver diseasenonalcoholic steatohepatitisgrowth hormone deficiencyprevalence |
| spellingShingle | Tingting Kong Yunpeng Gu Lei Sun Run Zhou Jie Li Junping Shi Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis Endocrine Journal nonalcoholic fatty liver disease nonalcoholic steatohepatitis growth hormone deficiency prevalence |
| title | Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis |
| title_full | Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis |
| title_fullStr | Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis |
| title_full_unstemmed | Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis |
| title_short | Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis |
| title_sort | association of nonalcoholic fatty liver disease and growth hormone deficiency a systematic review and meta analysis |
| topic | nonalcoholic fatty liver disease nonalcoholic steatohepatitis growth hormone deficiency prevalence |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0157/_html/-char/en |
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