Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance
Background. The enzyme dipeptidyl peptidase 4 (DPP4) has been recently recognized as an adipo-myokine. However, studies that associate its constitutive activity with body composition, anthropometry, and insulin resistance (IR) are very scarce and included only healthy people. Methods. First, we inve...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5238013 |
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| author | Wellington S. Silva Júnior Maria das Graças C. Souza José Firmino Nogueira Neto Eliete Bouskela Luiz Guilherme Kraemer-Aguiar |
| author_facet | Wellington S. Silva Júnior Maria das Graças C. Souza José Firmino Nogueira Neto Eliete Bouskela Luiz Guilherme Kraemer-Aguiar |
| author_sort | Wellington S. Silva Júnior |
| collection | DOAJ |
| description | Background. The enzyme dipeptidyl peptidase 4 (DPP4) has been recently recognized as an adipo-myokine. However, studies that associate its constitutive activity with body composition, anthropometry, and insulin resistance (IR) are very scarce and included only healthy people. Methods. First, we investigated the relationships of constitutive DPP4 activity, body composition (assessed by bioelectrical impedance analysis), and measures of adiposity and IR in fifty-two subjects of both sexes, 18-50 years, and BMI ≥25.0 kg/m2 who comprised three groups according to glucose tolerance. Additionally, we evaluated associations among DPP4 activity and adipokines, gut peptides, and biochemical variables at fasting and 30 and 60 min after a standardized meal intake. Results. DPP4 activity was no different among the three groups. At fasting, pooled analysis showed it was positively correlated with measures of central adiposity, such as WC (P=0.011) and WHR (P=0.009), and with all measures of IR, but inversely related to indexes of general adiposity, such as fat mass percentage (P=0.014) and BAI (P=0.0003). DPP4 activity was also associated with lean mass (r=0.57, P<0.0001). After meal intake, DPP4 activity remained significantly associated with insulin, leptin, and resistin. In multiple regression analysis, BAI, WHR, percent lean mass, HOMA-IR, and leptin influenced DPP4 activity and explained approximately 26% of the variance on it. Conclusions. Constitutive DPP4 activity is positively associated with lean mass, central adiposity, and IR and negatively to general adiposity. Furthermore, it seems to be influenced by body composition and IR and could also be viewed as an adipo-myokine in subjects with excessive adiposity and different stages of glucose tolerance. |
| format | Article |
| id | doaj-art-4149eef1978b4837b3d5aea741f18d38 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4149eef1978b4837b3d5aea741f18d382025-02-03T06:14:01ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/52380135238013Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose ToleranceWellington S. Silva Júnior0Maria das Graças C. Souza1José Firmino Nogueira Neto2Eliete Bouskela3Luiz Guilherme Kraemer-Aguiar4Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ 20551-030, BrazilLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), UERJ, Rio de Janeiro, RJ 20550-013, BrazilLaboratory of Lipids (LABLIP), UERJ, Rio de Janeiro, RJ 20551-030, BrazilPostgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ 20551-030, BrazilLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), UERJ, Rio de Janeiro, RJ 20550-013, BrazilBackground. The enzyme dipeptidyl peptidase 4 (DPP4) has been recently recognized as an adipo-myokine. However, studies that associate its constitutive activity with body composition, anthropometry, and insulin resistance (IR) are very scarce and included only healthy people. Methods. First, we investigated the relationships of constitutive DPP4 activity, body composition (assessed by bioelectrical impedance analysis), and measures of adiposity and IR in fifty-two subjects of both sexes, 18-50 years, and BMI ≥25.0 kg/m2 who comprised three groups according to glucose tolerance. Additionally, we evaluated associations among DPP4 activity and adipokines, gut peptides, and biochemical variables at fasting and 30 and 60 min after a standardized meal intake. Results. DPP4 activity was no different among the three groups. At fasting, pooled analysis showed it was positively correlated with measures of central adiposity, such as WC (P=0.011) and WHR (P=0.009), and with all measures of IR, but inversely related to indexes of general adiposity, such as fat mass percentage (P=0.014) and BAI (P=0.0003). DPP4 activity was also associated with lean mass (r=0.57, P<0.0001). After meal intake, DPP4 activity remained significantly associated with insulin, leptin, and resistin. In multiple regression analysis, BAI, WHR, percent lean mass, HOMA-IR, and leptin influenced DPP4 activity and explained approximately 26% of the variance on it. Conclusions. Constitutive DPP4 activity is positively associated with lean mass, central adiposity, and IR and negatively to general adiposity. Furthermore, it seems to be influenced by body composition and IR and could also be viewed as an adipo-myokine in subjects with excessive adiposity and different stages of glucose tolerance.http://dx.doi.org/10.1155/2019/5238013 |
| spellingShingle | Wellington S. Silva Júnior Maria das Graças C. Souza José Firmino Nogueira Neto Eliete Bouskela Luiz Guilherme Kraemer-Aguiar Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance Journal of Diabetes Research |
| title | Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance |
| title_full | Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance |
| title_fullStr | Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance |
| title_full_unstemmed | Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance |
| title_short | Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance |
| title_sort | dipeptidyl peptidase 4 activity is related to body composition measures of adiposity and insulin resistance in subjects with excessive adiposity and different degrees of glucose tolerance |
| url | http://dx.doi.org/10.1155/2019/5238013 |
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