Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity
Amiodarone is an iodinated benzofuran derivative class III antiarrhythmic that is highly effective in suppressing ventricular and supraventricular arrhythmias. It is also associated with an imposing side effect profile, which often limits its use. Numerous adverse effects have been documented includ...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2000/139581 |
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| _version_ | 1832547628849561600 |
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| author | Karen EA Burns Eugenia Piliotis Bertha M Garcia Kathleen A Ferguson |
| author_facet | Karen EA Burns Eugenia Piliotis Bertha M Garcia Kathleen A Ferguson |
| author_sort | Karen EA Burns |
| collection | DOAJ |
| description | Amiodarone is an iodinated benzofuran derivative class III antiarrhythmic that is highly effective in suppressing ventricular and supraventricular arrhythmias. It is also associated with an imposing side effect profile, which often limits its use. Numerous adverse effects have been documented including skin discolouration, photosensitivity, hepatitis, thyroid dysfunction, corneal deposits, pulmonary fibrosis, bone marrow suppression and drug interactions. These side effects are thought to be correlated with the total cumulative dose of amiodarone, but idiopathic reactions have been reported. The majority of adverse reactions resolve with discontinuation of the drug; however, rapid progression may occur, which may be fatal. The present report documents a patient who had a combination of serious amiodarone toxicities that, once recognized, were treated and eventually resulted in a good outcome. |
| format | Article |
| id | doaj-art-4138d02a4c434f33afffa00d87a52584 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-4138d02a4c434f33afffa00d87a525842025-02-03T06:43:53ZengWileyCanadian Respiratory Journal1198-22412000-01-017219319710.1155/2000/139581Amiodarone Pulmonary, Neuromuscular and Ophthalmologic ToxicityKaren EA Burns0Eugenia Piliotis1Bertha M Garcia2Kathleen A Ferguson3Divisions of Respirology and Critical Care, Department of Medicine, University of Western Ontario, CanadaInternal Medicine, Department of Medicine, University of Western Ontario, CanadaDepartment of Pathology, University of Western Ontario, CanadaDivision of Respirology, Department of Medicine, University of Western Ontario, London, Ontario, CanadaAmiodarone is an iodinated benzofuran derivative class III antiarrhythmic that is highly effective in suppressing ventricular and supraventricular arrhythmias. It is also associated with an imposing side effect profile, which often limits its use. Numerous adverse effects have been documented including skin discolouration, photosensitivity, hepatitis, thyroid dysfunction, corneal deposits, pulmonary fibrosis, bone marrow suppression and drug interactions. These side effects are thought to be correlated with the total cumulative dose of amiodarone, but idiopathic reactions have been reported. The majority of adverse reactions resolve with discontinuation of the drug; however, rapid progression may occur, which may be fatal. The present report documents a patient who had a combination of serious amiodarone toxicities that, once recognized, were treated and eventually resulted in a good outcome.http://dx.doi.org/10.1155/2000/139581 |
| spellingShingle | Karen EA Burns Eugenia Piliotis Bertha M Garcia Kathleen A Ferguson Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity Canadian Respiratory Journal |
| title | Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity |
| title_full | Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity |
| title_fullStr | Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity |
| title_full_unstemmed | Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity |
| title_short | Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity |
| title_sort | amiodarone pulmonary neuromuscular and ophthalmologic toxicity |
| url | http://dx.doi.org/10.1155/2000/139581 |
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