Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid
Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240525000029 |
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| author | Beibei Lu Zhenyuan Wang Ying Xu Yue Liu Bo Ruan Jichuan Zhang Jianglin Zhang Jiaheng Zhang Tao Zhang |
| author_facet | Beibei Lu Zhenyuan Wang Ying Xu Yue Liu Bo Ruan Jichuan Zhang Jianglin Zhang Jiaheng Zhang Tao Zhang |
| author_sort | Beibei Lu |
| collection | DOAJ |
| description | Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance transdermal permeability and solve irritation. The results of the monomer of bakuchiol showed that the ionic liquid-loaded bakuchiol significantly improved the skin permeability of bakuchiol and completely solved the problem of low irritation of bakuchiol. As a single component, its penetration rate is 4.17 times that of retinol and 3.48 times that of bakuchiol, therefore it has a stronger inflammation inhibition rate and collagen expression ability (increasing the expression of col 1a1a, col 1a1b, and col 1a2). As a substitute for retinol, bakuchiol has great potential in anti-aging applications. |
| format | Article |
| id | doaj-art-413086e46f6c4fd9a767d16c81f36d10 |
| institution | Kabale University |
| issn | 2667-2405 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Supramolecular Materials |
| spelling | doaj-art-413086e46f6c4fd9a767d16c81f36d102025-01-18T05:05:28ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052025-12-014100093Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquidBeibei Lu0Zhenyuan Wang1Ying Xu2Yue Liu3Bo Ruan4Jichuan Zhang5Jianglin Zhang6Jiaheng Zhang7Tao Zhang8School of Pharmacy, Guangzhou Huali College, Guangzhou 511325, PR China; Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, PR China; Sauvage Laboratory for Smart Materials, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, PR China; Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, PR ChinaShenzhen Shinehigh Innovation Technology Co., Ltd. Shenzhen 518055, PR ChinaResearch and Innovation Laboratory, Better Way (Shanghai) Cosmetics Co., Ltd. Shanghai 201400, PR China; Corresponding authors.Research and Innovation Laboratory, Better Way (Shanghai) Cosmetics Co., Ltd. Shanghai 201400, PR ChinaShenzhen Shinehigh Innovation Technology Co., Ltd. Shenzhen 518055, PR ChinaShenzhen Shinehigh Innovation Technology Co., Ltd. Shenzhen 518055, PR ChinaDepartment of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, PR ChinaSauvage Laboratory for Smart Materials, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, PR China; Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, PR China; Correspondence author at: Sauvage Laboratory for Smart Materials, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, PR China.Research and Innovation Laboratory, Better Way (Shanghai) Cosmetics Co., Ltd. Shanghai 201400, PR China; Corresponding authors.Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance transdermal permeability and solve irritation. The results of the monomer of bakuchiol showed that the ionic liquid-loaded bakuchiol significantly improved the skin permeability of bakuchiol and completely solved the problem of low irritation of bakuchiol. As a single component, its penetration rate is 4.17 times that of retinol and 3.48 times that of bakuchiol, therefore it has a stronger inflammation inhibition rate and collagen expression ability (increasing the expression of col 1a1a, col 1a1b, and col 1a2). As a substitute for retinol, bakuchiol has great potential in anti-aging applications.http://www.sciencedirect.com/science/article/pii/S2667240525000029Ionic liquidSupramolecular bakuchiolAnti-wrinkleTransdermal deliveryAnti-aging |
| spellingShingle | Beibei Lu Zhenyuan Wang Ying Xu Yue Liu Bo Ruan Jichuan Zhang Jianglin Zhang Jiaheng Zhang Tao Zhang Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid Supramolecular Materials Ionic liquid Supramolecular bakuchiol Anti-wrinkle Transdermal delivery Anti-aging |
| title | Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| title_full | Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| title_fullStr | Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| title_full_unstemmed | Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| title_short | Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| title_sort | anti aging and anti inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid |
| topic | Ionic liquid Supramolecular bakuchiol Anti-wrinkle Transdermal delivery Anti-aging |
| url | http://www.sciencedirect.com/science/article/pii/S2667240525000029 |
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