Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis
<i>Background and Objectives</i>: Retroperitoneal laparoscopic adrenalectomy (RLA) is one of two laparoscopic procedures used to treat benign and malignant adrenal diseases. Obesity in patients undergoing minimally invasive adrenal surgery is a frequently discussed topic. Our meta-analys...
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2025-01-01
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| author | Maurizio Zizzo Andrea Morini Magda Zanelli Chiara Grasselli Francesca Sanguedolce Sze Ling Wong Munyaradzi G. Nyandoro Andrea Palicelli Giuseppe Broggi Nektarios I. Koufopoulos Lucia Mangone Angelo Cormio Rosario Caltabiano Antonino Neri Massimiliano Fabozzi |
| author_facet | Maurizio Zizzo Andrea Morini Magda Zanelli Chiara Grasselli Francesca Sanguedolce Sze Ling Wong Munyaradzi G. Nyandoro Andrea Palicelli Giuseppe Broggi Nektarios I. Koufopoulos Lucia Mangone Angelo Cormio Rosario Caltabiano Antonino Neri Massimiliano Fabozzi |
| author_sort | Maurizio Zizzo |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Retroperitoneal laparoscopic adrenalectomy (RLA) is one of two laparoscopic procedures used to treat benign and malignant adrenal diseases. Obesity in patients undergoing minimally invasive adrenal surgery is a frequently discussed topic. Our meta-analysis aimed to provide updated evidence by comparing intraoperative and perioperative outcomes on non-obese (NOb) and obese (Ob) patients who underwent RLA due to benign or malignant disease. <i>Materials and Methods</i>: We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed/MEDLINE, Scopus, Web of Science (Science and Social Science Citation Index), and Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL)) databases were used to identify articles of interest. The meta-analysis was performed using RevMan [Computer program] Version 5.4. <i>Results</i>: The four included comparative studies (809 patients: 552 NOb versus 257 Ob) covered an approximately 15-year-study period (2007–2022). All the included studies were observational in nature. By comparing the Ob and NOb groups, shorter operative time and lower overall postoperative complication rates in the NOb population were recorded through the meta-analysis. Considering the subgroup analysis (BMI ≥ 30 kg/m<sup>2</sup>), just the operative time maintained statistical significance. <i>Conclusions</i>: Obesity did not appear to impact RLA safety and effectiveness. Due to important biases (small overall sample size and few analyzed events), the interpretation of our results must be a careful one. Later randomized and multi-center trials may help the confirmation of our results. |
| format | Article |
| id | doaj-art-412b69c1d6514c08a74602a0ead8235d |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-412b69c1d6514c08a74602a0ead8235d2025-01-24T13:40:38ZengMDPI AGMedicina1010-660X1648-91442025-01-0161110610.3390/medicina61010106Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-AnalysisMaurizio Zizzo0Andrea Morini1Magda Zanelli2Chiara Grasselli3Francesca Sanguedolce4Sze Ling Wong5Munyaradzi G. Nyandoro6Andrea Palicelli7Giuseppe Broggi8Nektarios I. Koufopoulos9Lucia Mangone10Angelo Cormio11Rosario Caltabiano12Antonino Neri13Massimiliano Fabozzi14Surgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalySurgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyCardiovascular Medicine Unit and Secondary Hypertension Center, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, 71122 Foggia, ItalyGeneral and Endocrine Surgery, Royal Perth Hospital, Perth, WA 6000, AustraliaGeneral and Endocrine Surgery, Royal Perth Hospital, Perth, WA 6000, AustraliaPathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalySecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, GreeceEpidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyUrology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Università Politecnica Delle Marche, 60126 Ancona, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalyScientific Directorate, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalySurgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy<i>Background and Objectives</i>: Retroperitoneal laparoscopic adrenalectomy (RLA) is one of two laparoscopic procedures used to treat benign and malignant adrenal diseases. Obesity in patients undergoing minimally invasive adrenal surgery is a frequently discussed topic. Our meta-analysis aimed to provide updated evidence by comparing intraoperative and perioperative outcomes on non-obese (NOb) and obese (Ob) patients who underwent RLA due to benign or malignant disease. <i>Materials and Methods</i>: We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed/MEDLINE, Scopus, Web of Science (Science and Social Science Citation Index), and Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL)) databases were used to identify articles of interest. The meta-analysis was performed using RevMan [Computer program] Version 5.4. <i>Results</i>: The four included comparative studies (809 patients: 552 NOb versus 257 Ob) covered an approximately 15-year-study period (2007–2022). All the included studies were observational in nature. By comparing the Ob and NOb groups, shorter operative time and lower overall postoperative complication rates in the NOb population were recorded through the meta-analysis. Considering the subgroup analysis (BMI ≥ 30 kg/m<sup>2</sup>), just the operative time maintained statistical significance. <i>Conclusions</i>: Obesity did not appear to impact RLA safety and effectiveness. Due to important biases (small overall sample size and few analyzed events), the interpretation of our results must be a careful one. Later randomized and multi-center trials may help the confirmation of our results.https://www.mdpi.com/1648-9144/61/1/106adrenal glandadrenalectomylaparoscopysurgeryobesitybody mass index |
| spellingShingle | Maurizio Zizzo Andrea Morini Magda Zanelli Chiara Grasselli Francesca Sanguedolce Sze Ling Wong Munyaradzi G. Nyandoro Andrea Palicelli Giuseppe Broggi Nektarios I. Koufopoulos Lucia Mangone Angelo Cormio Rosario Caltabiano Antonino Neri Massimiliano Fabozzi Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis Medicina adrenal gland adrenalectomy laparoscopy surgery obesity body mass index |
| title | Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis |
| title_full | Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis |
| title_fullStr | Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis |
| title_full_unstemmed | Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis |
| title_short | Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Analysis |
| title_sort | impact of obesity on short term outcomes in patients undergoing retroperitoneal laparoscopic retroperitoneoscopic adrenalectomy for benign or malignant adrenal diseases a meta analysis |
| topic | adrenal gland adrenalectomy laparoscopy surgery obesity body mass index |
| url | https://www.mdpi.com/1648-9144/61/1/106 |
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