The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection
Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between fe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1519273/full |
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| author | Zhaoshan Zhang Zhaoshan Zhang Zhaoshan Zhang Haichao Wang Haichao Wang Haichao Wang Xi Kan Xi Kan Xi Kan Xiaozhao Zhang Xiaozhao Zhang Xiaozhao Zhang Senping Xu Senping Xu Senping Xu Jie Cai Jie Cai Jie Cai Jiawei Guo Jiawei Guo Jiawei Guo |
| author_facet | Zhaoshan Zhang Zhaoshan Zhang Zhaoshan Zhang Haichao Wang Haichao Wang Haichao Wang Xi Kan Xi Kan Xi Kan Xiaozhao Zhang Xiaozhao Zhang Xiaozhao Zhang Senping Xu Senping Xu Senping Xu Jie Cai Jie Cai Jie Cai Jiawei Guo Jiawei Guo Jiawei Guo |
| author_sort | Zhaoshan Zhang |
| collection | DOAJ |
| description | Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall’s structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD. |
| format | Article |
| id | doaj-art-412aba1bb6794707b5b9e810e1dfec96 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-412aba1bb6794707b5b9e810e1dfec962025-02-05T05:17:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15192731519273The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissectionZhaoshan Zhang0Zhaoshan Zhang1Zhaoshan Zhang2Haichao Wang3Haichao Wang4Haichao Wang5Xi Kan6Xi Kan7Xi Kan8Xiaozhao Zhang9Xiaozhao Zhang10Xiaozhao Zhang11Senping Xu12Senping Xu13Senping Xu14Jie Cai15Jie Cai16Jie Cai17Jiawei Guo18Jiawei Guo19Jiawei Guo20Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, ChinaDepartment of Pharmacology, School of Medicine, Yangtze University, Jingzhou, ChinaAortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall’s structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD.https://www.frontiersin.org/articles/10.3389/fphar.2025.1519273/fullaortic dissectionferroptosisvascular smooth muscle cellsoxidative stressROSendothelial cells |
| spellingShingle | Zhaoshan Zhang Zhaoshan Zhang Zhaoshan Zhang Haichao Wang Haichao Wang Haichao Wang Xi Kan Xi Kan Xi Kan Xiaozhao Zhang Xiaozhao Zhang Xiaozhao Zhang Senping Xu Senping Xu Senping Xu Jie Cai Jie Cai Jie Cai Jiawei Guo Jiawei Guo Jiawei Guo The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection Frontiers in Pharmacology aortic dissection ferroptosis vascular smooth muscle cells oxidative stress ROS endothelial cells |
| title | The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| title_full | The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| title_fullStr | The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| title_full_unstemmed | The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| title_short | The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| title_sort | interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection |
| topic | aortic dissection ferroptosis vascular smooth muscle cells oxidative stress ROS endothelial cells |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1519273/full |
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