The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection

The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection

Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between fe...

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Bibliographic Details
Main Authors: Zhaoshan Zhang, Haichao Wang, Xi Kan, Xiaozhao Zhang, Senping Xu, Jie Cai, Jiawei Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
aortic dissection
ferroptosis
vascular smooth muscle cells
oxidative stress
ROS
endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1519273/full
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Summary:Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall’s structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD.
ISSN:1663-9812

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