Multiparameter flow cytometric and transcriptional analyis of CD20 positive T-cells in bone marrow in patients of multiple myeloma and monoclonal gammopathy of undetermined significance

Multiparameter flow cytometric and transcriptional analyis of CD20 positive T-cells in bone marrow in patients of multiple myeloma and monoclonal gammopathy of undetermined significance

IntroductionCD20+ T-cells were described firstly in peripheral blood and later in bone marrow in patients with hematological tumors, and certain immune-mediated diseases. During our hematological diagnostic work, this peculiar subgroup of lymphocytes has been consistently observed associated with un...

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Main Authors: Barbara Forró, Béla Kajtár, Ágnes Lacza, László Kereskai, Livia Vida, Balázs Kőszegi, Péter Urbán, József Kun, Attila Gyenesei, Szabolcs Kosztolányi, Dániel Kehl, Pál Jáksó
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
CD20
T-cells
tumor immunology
T-cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1464940/full
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