Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial
Abstract Background Acetaminophen is a widely used analgesic for postoperative pain management. However, data on its combined use with nefopam for managing postoperative pain following laparoscopic hysterectomy are limited. This study evaluated the effects of a single intravenous dose of acetaminoph...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-025-02971-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723790533066752 |
|---|---|
| author | Seungpyo Nam Seokha Yoo Sun-Kyung Park Jin-Tae Kim |
| author_facet | Seungpyo Nam Seokha Yoo Sun-Kyung Park Jin-Tae Kim |
| author_sort | Seungpyo Nam |
| collection | DOAJ |
| description | Abstract Background Acetaminophen is a widely used analgesic for postoperative pain management. However, data on its combined use with nefopam for managing postoperative pain following laparoscopic hysterectomy are limited. This study evaluated the effects of a single intravenous dose of acetaminophen combined with fentanyl- and nefopam-based patient-controlled analgesia (PCA) in patients undergoing laparoscopic hysterectomy. Methods In this prospective, double-blind, randomized controlled trial, 84 patients were randomized to receive either 1 g of intravenous acetaminophen (treatment group, n = 42) or normal saline (control group, n = 42) at the end of surgery. All patients received fentanyl and nefopam via PCA, postoperatively. PCA consumption, pain scores at rest, and postoperative nausea and vomiting (PONV) scores were assessed at 1, 6, and 24 h postoperatively. Patient satisfaction and opioid-related side effects were also evaluated. The primary outcome was the total PCA consumption within the first 24 h. Results No significant difference in 24-h PCA consumption was observed between the control and treatment groups (27.9 ± 16.6 vs. 26.4 ± 11.2, P = 0.623). The pain scores at rest measured at 1, 6, and 24 h after surgery were also not significantly different between the two groups. There were no differences in the satisfaction scores, PONV scores, rescue analgesic use, adverse effects, or length of hospital stay between the groups. Conclusions A single intraoperative dose of intravenous acetaminophen, combined with nefopam- and fentanyl-based PCA, did not significantly reduce analgesic requirements, pain scores at rest, or opioid-related side effects compared with placebo in laparoscopic hysterectomy patients. Trial registration ClinicalTrials.gov (Identifier: NCT03644147 | August 21, 2018). |
| format | Article |
| id | doaj-art-40f7e77dbd7f4e61ab96b2bb9af5c96e |
| institution | DOAJ |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-40f7e77dbd7f4e61ab96b2bb9af5c96e2025-08-20T03:10:56ZengBMCBMC Anesthesiology1471-22532025-02-012511810.1186/s12871-025-02971-wAdditive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trialSeungpyo Nam0Seokha Yoo1Sun-Kyung Park2Jin-Tae Kim3Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of MedicineDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of MedicineDepartment of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of MedicineDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of MedicineAbstract Background Acetaminophen is a widely used analgesic for postoperative pain management. However, data on its combined use with nefopam for managing postoperative pain following laparoscopic hysterectomy are limited. This study evaluated the effects of a single intravenous dose of acetaminophen combined with fentanyl- and nefopam-based patient-controlled analgesia (PCA) in patients undergoing laparoscopic hysterectomy. Methods In this prospective, double-blind, randomized controlled trial, 84 patients were randomized to receive either 1 g of intravenous acetaminophen (treatment group, n = 42) or normal saline (control group, n = 42) at the end of surgery. All patients received fentanyl and nefopam via PCA, postoperatively. PCA consumption, pain scores at rest, and postoperative nausea and vomiting (PONV) scores were assessed at 1, 6, and 24 h postoperatively. Patient satisfaction and opioid-related side effects were also evaluated. The primary outcome was the total PCA consumption within the first 24 h. Results No significant difference in 24-h PCA consumption was observed between the control and treatment groups (27.9 ± 16.6 vs. 26.4 ± 11.2, P = 0.623). The pain scores at rest measured at 1, 6, and 24 h after surgery were also not significantly different between the two groups. There were no differences in the satisfaction scores, PONV scores, rescue analgesic use, adverse effects, or length of hospital stay between the groups. Conclusions A single intraoperative dose of intravenous acetaminophen, combined with nefopam- and fentanyl-based PCA, did not significantly reduce analgesic requirements, pain scores at rest, or opioid-related side effects compared with placebo in laparoscopic hysterectomy patients. Trial registration ClinicalTrials.gov (Identifier: NCT03644147 | August 21, 2018).https://doi.org/10.1186/s12871-025-02971-wAcetaminophenFentanylNefopamPostoperative pain controlPatient-controlled analgesia |
| spellingShingle | Seungpyo Nam Seokha Yoo Sun-Kyung Park Jin-Tae Kim Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial BMC Anesthesiology Acetaminophen Fentanyl Nefopam Postoperative pain control Patient-controlled analgesia |
| title | Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial |
| title_full | Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial |
| title_fullStr | Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial |
| title_full_unstemmed | Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial |
| title_short | Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial |
| title_sort | additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl based patient controlled analgesia a double blind randomized controlled trial |
| topic | Acetaminophen Fentanyl Nefopam Postoperative pain control Patient-controlled analgesia |
| url | https://doi.org/10.1186/s12871-025-02971-w |
| work_keys_str_mv | AT seungpyonam additiveeffectofasingleintravenousdoseofacetaminophenadministeredattheendoflaparoscopichysterectomyonpostoperativepaincontrolwithnefopamandfentanylbasedpatientcontrolledanalgesiaadoubleblindrandomizedcontrolledtrial AT seokhayoo additiveeffectofasingleintravenousdoseofacetaminophenadministeredattheendoflaparoscopichysterectomyonpostoperativepaincontrolwithnefopamandfentanylbasedpatientcontrolledanalgesiaadoubleblindrandomizedcontrolledtrial AT sunkyungpark additiveeffectofasingleintravenousdoseofacetaminophenadministeredattheendoflaparoscopichysterectomyonpostoperativepaincontrolwithnefopamandfentanylbasedpatientcontrolledanalgesiaadoubleblindrandomizedcontrolledtrial AT jintaekim additiveeffectofasingleintravenousdoseofacetaminophenadministeredattheendoflaparoscopichysterectomyonpostoperativepaincontrolwithnefopamandfentanylbasedpatientcontrolledanalgesiaadoubleblindrandomizedcontrolledtrial |