Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications
The synthesis of nanomaterials with diverse biomedical and catalytic potentials is crucial in this era of rapidly advancing technology and increasing demand for innovative solutions in medicine and catalysis. The current study explores Leptochloa fusca aqueous extract for the eco-benign and cost-eff...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/adaa55 |
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| author | Riaz Ahmad Khan Hidayat Ullah Khan Shahnaz Kamran Tahir Moamen S Refat Abdel Majid A Adam Amnah Mohammed Alsuhaibani |
| author_facet | Riaz Ahmad Khan Hidayat Ullah Khan Shahnaz Kamran Tahir Moamen S Refat Abdel Majid A Adam Amnah Mohammed Alsuhaibani |
| author_sort | Riaz Ahmad Khan |
| collection | DOAJ |
| description | The synthesis of nanomaterials with diverse biomedical and catalytic potentials is crucial in this era of rapidly advancing technology and increasing demand for innovative solutions in medicine and catalysis. The current study explores Leptochloa fusca aqueous extract for the eco-benign and cost-effective green synthesis of multifunctional silver nanoparticles (LF-AgNPs) with enormous potential of biomedical and catalytic applications. The bio-fabricated nanoparticles were characterized employing various analytical techniques including UV–Visible, FTIR, XRD, EDX, SEM and TGA. These analyses confirmed the synthesis, chemical composition, size, morphology, crystalline nature and thermal stability of LF-AgNPs. The surface plasmon resonance of LF-AgNPs was recorded at 432–436 nm and the particle size measured via SEM analysis was noted to be 30 to 200 nm. The synthesized LF-AgNPs were examined for their biomedical and catalytic applications. The binding affinity of LF-AgNPs with ssDNA and BSA was ratified spectroscopically by UV–Visible and FTIR techniques. The hyperchromism observed in the UV–vis absorption spectra, as well as changes in the FTIR spectra of ssDNA and BSA upon interaction with LF-AgNPs, indicate the formation of LF-AgNPs–ssDNA and LF-AgNPs–BSA complexes. This type of binding results in conformational changes in ssDNA and BSA structures and therefore LF-AgNPs hold potential for numerous applications like drug delivery, anticancer agents and receptor targeting. The biosynthesized LF-AgNPs were also found to have effective antioxidant (70%) and H _2 O _2 scavenging (77%) properties. Additionally, the agar well diffusion technique demonstrated efficient antibacterial efficacy for LF-AgNPs against both Gram +ve ( Staphylococcus aureus ) and Gram -ve ( Klebsiella pneumoniae ) strains with ZOI values of 19 ± 0.7 mm and 19 ± 0.5 mm, respectively. LF-AgNPs efficiently catalysed the reduction of methylene blue in less than 9 min, using NaBH _4 as a reducing agent. These findings suggest that LF-AgNPs exhibit significant capability for integration into catalytic process of MB reduction and selected biomedical applications. |
| format | Article |
| id | doaj-art-40ed4710be3f499882a0c906456bd865 |
| institution | Kabale University |
| issn | 2053-1591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-40ed4710be3f499882a0c906456bd8652025-01-24T15:49:24ZengIOP PublishingMaterials Research Express2053-15912025-01-0112101500610.1088/2053-1591/adaa55Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applicationsRiaz Ahmad Khan0https://orcid.org/0000-0002-0401-5299Hidayat Ullah Khan1Shahnaz2https://orcid.org/0000-0002-3817-2866Kamran Tahir3https://orcid.org/0000-0001-9505-1414Moamen S Refat4Abdel Majid A Adam5Amnah Mohammed Alsuhaibani6Department of Chemistry, University of Science and Technology , Bannu (28100) KP, PakistanDepartment of Chemistry, University of Science and Technology , Bannu (28100) KP, PakistanDepartment of Chemistry, University of Science and Technology , Bannu (28100) KP, PakistanInstitute of Chemical Sciences, Gomal University , D.I.Khan, KP, PakistanDepartment of Chemistry, College of Science, Taif University , PO Box 11099, Taif 21944, Saudi ArabiaDepartment of Chemistry, College of Science, Taif University , PO Box 11099, Taif 21944, Saudi ArabiaDepartment of Physical Sport Sciences, College of Sport Sciences & Physical Activity, Princess Nourah bint Abdulrahman University , PO Box 84428, Riyadh 11671, Saudi ArabiaThe synthesis of nanomaterials with diverse biomedical and catalytic potentials is crucial in this era of rapidly advancing technology and increasing demand for innovative solutions in medicine and catalysis. The current study explores Leptochloa fusca aqueous extract for the eco-benign and cost-effective green synthesis of multifunctional silver nanoparticles (LF-AgNPs) with enormous potential of biomedical and catalytic applications. The bio-fabricated nanoparticles were characterized employing various analytical techniques including UV–Visible, FTIR, XRD, EDX, SEM and TGA. These analyses confirmed the synthesis, chemical composition, size, morphology, crystalline nature and thermal stability of LF-AgNPs. The surface plasmon resonance of LF-AgNPs was recorded at 432–436 nm and the particle size measured via SEM analysis was noted to be 30 to 200 nm. The synthesized LF-AgNPs were examined for their biomedical and catalytic applications. The binding affinity of LF-AgNPs with ssDNA and BSA was ratified spectroscopically by UV–Visible and FTIR techniques. The hyperchromism observed in the UV–vis absorption spectra, as well as changes in the FTIR spectra of ssDNA and BSA upon interaction with LF-AgNPs, indicate the formation of LF-AgNPs–ssDNA and LF-AgNPs–BSA complexes. This type of binding results in conformational changes in ssDNA and BSA structures and therefore LF-AgNPs hold potential for numerous applications like drug delivery, anticancer agents and receptor targeting. The biosynthesized LF-AgNPs were also found to have effective antioxidant (70%) and H _2 O _2 scavenging (77%) properties. Additionally, the agar well diffusion technique demonstrated efficient antibacterial efficacy for LF-AgNPs against both Gram +ve ( Staphylococcus aureus ) and Gram -ve ( Klebsiella pneumoniae ) strains with ZOI values of 19 ± 0.7 mm and 19 ± 0.5 mm, respectively. LF-AgNPs efficiently catalysed the reduction of methylene blue in less than 9 min, using NaBH _4 as a reducing agent. These findings suggest that LF-AgNPs exhibit significant capability for integration into catalytic process of MB reduction and selected biomedical applications.https://doi.org/10.1088/2053-1591/adaa55silver nanoparticlesleptochloa fuscaantibacterial activityssDNA and BSA proteinsilver nanoparticlesleptochloa fusca |
| spellingShingle | Riaz Ahmad Khan Hidayat Ullah Khan Shahnaz Kamran Tahir Moamen S Refat Abdel Majid A Adam Amnah Mohammed Alsuhaibani Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications Materials Research Express silver nanoparticles leptochloa fusca antibacterial activity ssDNA and BSA protein silver nanoparticles leptochloa fusca |
| title | Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| title_full | Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| title_fullStr | Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| title_full_unstemmed | Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| title_short | Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| title_sort | eco benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications |
| topic | silver nanoparticles leptochloa fusca antibacterial activity ssDNA and BSA protein silver nanoparticles leptochloa fusca |
| url | https://doi.org/10.1088/2053-1591/adaa55 |
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