Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context
Summary: Background: HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. This study assessed oral HPV prevalence and risk-factors among a general population in Europe and the Unit...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024005972 |
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| author | Laia Alemany Marisa Felsher Anna R. Giuliano Tim Waterboer Haitham Mirghani Hisham Mehanna Craig Roberts Ya-Ting Chen Núria Lara Mark Lynam Mayara Torres Montse Pedrós Emilio Sanchez Jacque Spitzer Bradley Sirak Beatriz Quirós Gema Carretero Sonia Paytubi Edith Morais Miquel Angel Pavón |
| author_facet | Laia Alemany Marisa Felsher Anna R. Giuliano Tim Waterboer Haitham Mirghani Hisham Mehanna Craig Roberts Ya-Ting Chen Núria Lara Mark Lynam Mayara Torres Montse Pedrós Emilio Sanchez Jacque Spitzer Bradley Sirak Beatriz Quirós Gema Carretero Sonia Paytubi Edith Morais Miquel Angel Pavón |
| author_sort | Laia Alemany |
| collection | DOAJ |
| description | Summary: Background: HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. This study assessed oral HPV prevalence and risk-factors among a general population in Europe and the United States (US). Methods: The cross-sectional study was conducted between November 2020 and July 2023 in 105 dental offices in France, Germany, Spain, the United Kingdom (UK) and US. Participants were aged 18–60 and visiting dental clinics for routine examination. Participants provided oral gargle specimen for HPV DNA and genotyping and completed behavioral questionnaires. HPV DNA detection and genotyping was performed using SPF10/DEIA/LiPA25 at central laboratories. Findings: Of 7674 participants, mean (SD) age was 40.0 (11.9), and 45.8% were males. Among men, any oral HPV prevalence ranged between countries from 6.6% to 15.0% and 1.8%–4.5% for high-risk (HR) types. Among women, any oral HPV prevalence ranged between countries from 3.6% to 6.8% and 0.2%–2.1% for HR types. HR infection among men was associated with older age (AOR 1.04; 95% CI: 1.02, 1.06); marijuana use (AOR 1.92; 95% CI: 1.19–3.11); increasing number of lifetime female oral sex partners; and by country, residing in the UK compared to Spain (AOR 2.89; 95% CI: 1.30–6.43). HR infection among women was associated with lifetime marijuana use (AOR 2.33; 95% CI: 1.18–4.60) and by country, residing in France compared to Spain (AOR 4.46; 95% CI: 1.26–15.77). Interpretation: Oral HPV burden was highest among older men who may be at risk of developing OPSCC. Funding: Funding for this research was provided by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. |
| format | Article |
| id | doaj-art-40e827b043d24dd7be40a7c56883d54f |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | EClinicalMedicine |
| spelling | doaj-art-40e827b043d24dd7be40a7c56883d54f2025-01-22T05:43:43ZengElsevierEClinicalMedicine2589-53702025-01-0179103018Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in contextLaia Alemany0Marisa Felsher1Anna R. Giuliano2Tim Waterboer3Haitham Mirghani4Hisham Mehanna5Craig Roberts6Ya-Ting Chen7Núria Lara8Mark Lynam9Mayara Torres10Montse Pedrós11Emilio Sanchez12Jacque Spitzer13Bradley Sirak14Beatriz Quirós15Gema Carretero16Sonia Paytubi17Edith Morais18Miquel Angel Pavón19Catalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, SpainMerck & Co., Inc., Rahway, NJ, 07065, USA; Corresponding author.Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, Florida, USA, 33612German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, GermanyHôpital Européen Georges-Pompidou, Assistance Publique - Hôpitaux de Paris, Université Paris Cité, 20 Rue Leblanc, 75015, Paris, FranceInstitute of Head & Neck Studies and Education (InHANSE), University of Birmingham, Robert Aitken Building, Vincent Drive, B15 2TT, Birmingham, United KingdomMerck & Co., Inc., Rahway, NJ, 07065, USAMerck & Co., Inc., Rahway, NJ, 07065, USAIQVIA, Provença, 392, 3rd Floor, 08025, Barcelona, SpainIQVIA, Provença, 392, 3rd Floor, 08025, Barcelona, SpainIQVIA, Provença, 392, 3rd Floor, 08025, Barcelona, SpainIQVIA, Provença, 392, 3rd Floor, 08025, Barcelona, SpainIQVIA, Provença, 392, 3rd Floor, 08025, Barcelona, SpainMerck & Co., Inc., Rahway, NJ, 07065, USACenter for Immunization and Infection Research in Cancer, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, Florida, USA, 33612Catalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, SpainCatalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, SpainCatalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, SpainMSD France, Puteaux, FranceCatalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, SpainSummary: Background: HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. This study assessed oral HPV prevalence and risk-factors among a general population in Europe and the United States (US). Methods: The cross-sectional study was conducted between November 2020 and July 2023 in 105 dental offices in France, Germany, Spain, the United Kingdom (UK) and US. Participants were aged 18–60 and visiting dental clinics for routine examination. Participants provided oral gargle specimen for HPV DNA and genotyping and completed behavioral questionnaires. HPV DNA detection and genotyping was performed using SPF10/DEIA/LiPA25 at central laboratories. Findings: Of 7674 participants, mean (SD) age was 40.0 (11.9), and 45.8% were males. Among men, any oral HPV prevalence ranged between countries from 6.6% to 15.0% and 1.8%–4.5% for high-risk (HR) types. Among women, any oral HPV prevalence ranged between countries from 3.6% to 6.8% and 0.2%–2.1% for HR types. HR infection among men was associated with older age (AOR 1.04; 95% CI: 1.02, 1.06); marijuana use (AOR 1.92; 95% CI: 1.19–3.11); increasing number of lifetime female oral sex partners; and by country, residing in the UK compared to Spain (AOR 2.89; 95% CI: 1.30–6.43). HR infection among women was associated with lifetime marijuana use (AOR 2.33; 95% CI: 1.18–4.60) and by country, residing in France compared to Spain (AOR 4.46; 95% CI: 1.26–15.77). Interpretation: Oral HPV burden was highest among older men who may be at risk of developing OPSCC. Funding: Funding for this research was provided by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.http://www.sciencedirect.com/science/article/pii/S2589537024005972Oral human papillomavirusPrevalenceRisk factors |
| spellingShingle | Laia Alemany Marisa Felsher Anna R. Giuliano Tim Waterboer Haitham Mirghani Hisham Mehanna Craig Roberts Ya-Ting Chen Núria Lara Mark Lynam Mayara Torres Montse Pedrós Emilio Sanchez Jacque Spitzer Bradley Sirak Beatriz Quirós Gema Carretero Sonia Paytubi Edith Morais Miquel Angel Pavón Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context EClinicalMedicine Oral human papillomavirus Prevalence Risk factors |
| title | Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context |
| title_full | Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context |
| title_fullStr | Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context |
| title_full_unstemmed | Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context |
| title_short | Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) studyResearch in context |
| title_sort | oral human papillomavirus hpv prevalence and genotyping among healthy adult populations in the united states and europe results from the progress prevalence of oral hpv infection a global assessment studyresearch in context |
| topic | Oral human papillomavirus Prevalence Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024005972 |
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