H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.

H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.

Channelopathies affecting the hyperpolarization-activated cyclic nucleotide gated (HCN or h-) channel and the Kv7 voltage gated m-type potassium (m-) channel present a paradox in epilepsy research: despite experimental evidence that both over- and underexpression of these channels can be epileptogen...

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Bibliographic Details
Main Authors: Scott Rich, Taufik A Valiante, Jérémie Lefebvre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013199
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