Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study
Objectives. Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS). We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS. Methods. We recruited 762 Chinese participant...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/3167875 |
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| _version_ | 1832568491998183424 |
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| author | Kuo Liu Bo Xi Zheng Liu Han Qi Bin Liu Jie Zhang Han Cao Yuxiang Yan Min Zhao Yan He Ling Zhang |
| author_facet | Kuo Liu Bo Xi Zheng Liu Han Qi Bin Liu Jie Zhang Han Cao Yuxiang Yan Min Zhao Yan He Ling Zhang |
| author_sort | Kuo Liu |
| collection | DOAJ |
| description | Objectives. Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS). We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS. Methods. We recruited 762 Chinese participants into the study. An unweighted PRS was constructed using 42 known genetic risk variants associated with SS or salt sensitivity blood pressure. A modified Sullivan’s acute oral saline load and diuresis shrinkage test was used to detect salt sensitivity. Logistic regression was used to estimate the joint effect of the SNPs on SS both overall and after stratification by hypertension. Results. The mean age of the participants was 57.1 years, and most of them were female (77.4%). The prevalence of SS was 28.7%. Both the continuous PRS and PRS tertiles were significantly associated with the risk of SS and a BP increase of more than 5 mmHg during acute salt loading but were not associated with a BP decrease of more than 10 mmHg during the diuresis shrinkage process. In the normotensive group, participants with PRSs in the middle and top tertiles had a more than twofold increased risk of SS (OR = 2.18, 95% CI: 1.15–4.12, P=0.016, and OR = 2.28, 95% CI: 1.19–4.38, P=0.013, respectively) compared with participants with PRSs in the first tertile. In the normotensive group, participants with PRSs in the middle tertile (OR = 1.94, 95% CI: 1.01–3.71, P=0.046) and top tertile (OR = 2.30, 95% CI: 1.19–4.44, P=0.013) had an increased risk of a greater than 5 mmHg increase in BP during acute salt loading than those with PRSs in the first tertile. In the hypertension group, neither the continuous PRS nor PRS tertile was significantly associated with the risk of SS. Conclusion. The 42 investigated SNPs were jointly and significantly associated with SS, especially in the normotensive Chinese population. These findings may provide genetic evidence for identifying target populations that would benefit from salt restriction policies. |
| format | Article |
| id | doaj-art-40d1b3bd32b24e93bbc81038bf873531 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-40d1b3bd32b24e93bbc81038bf8735312025-02-03T00:58:57ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/31678753167875Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS StudyKuo Liu0Bo Xi1Zheng Liu2Han Qi3Bin Liu4Jie Zhang5Han Cao6Yuxiang Yan7Min Zhao8Yan He9Ling Zhang10Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology, School of Public Health, Shandong University, Jinan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Food Hygiene and Nutrition, School of Public Health, Shandong University, Jinan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, ChinaObjectives. Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS). We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS. Methods. We recruited 762 Chinese participants into the study. An unweighted PRS was constructed using 42 known genetic risk variants associated with SS or salt sensitivity blood pressure. A modified Sullivan’s acute oral saline load and diuresis shrinkage test was used to detect salt sensitivity. Logistic regression was used to estimate the joint effect of the SNPs on SS both overall and after stratification by hypertension. Results. The mean age of the participants was 57.1 years, and most of them were female (77.4%). The prevalence of SS was 28.7%. Both the continuous PRS and PRS tertiles were significantly associated with the risk of SS and a BP increase of more than 5 mmHg during acute salt loading but were not associated with a BP decrease of more than 10 mmHg during the diuresis shrinkage process. In the normotensive group, participants with PRSs in the middle and top tertiles had a more than twofold increased risk of SS (OR = 2.18, 95% CI: 1.15–4.12, P=0.016, and OR = 2.28, 95% CI: 1.19–4.38, P=0.013, respectively) compared with participants with PRSs in the first tertile. In the normotensive group, participants with PRSs in the middle tertile (OR = 1.94, 95% CI: 1.01–3.71, P=0.046) and top tertile (OR = 2.30, 95% CI: 1.19–4.44, P=0.013) had an increased risk of a greater than 5 mmHg increase in BP during acute salt loading than those with PRSs in the first tertile. In the hypertension group, neither the continuous PRS nor PRS tertile was significantly associated with the risk of SS. Conclusion. The 42 investigated SNPs were jointly and significantly associated with SS, especially in the normotensive Chinese population. These findings may provide genetic evidence for identifying target populations that would benefit from salt restriction policies.http://dx.doi.org/10.1155/2020/3167875 |
| spellingShingle | Kuo Liu Bo Xi Zheng Liu Han Qi Bin Liu Jie Zhang Han Cao Yuxiang Yan Min Zhao Yan He Ling Zhang Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study International Journal of Hypertension |
| title | Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study |
| title_full | Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study |
| title_fullStr | Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study |
| title_full_unstemmed | Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study |
| title_short | Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study |
| title_sort | genetic predisposition and salt sensitivity in a chinese han population the episs study |
| url | http://dx.doi.org/10.1155/2020/3167875 |
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