L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release
<b>Background and objectives:</b> The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; <b>Methods:</b> In this study, L-threonine polyurethane (LTPU) NPs have been fabricated by water-i...
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2024-12-01
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| author | Seoeun Oh Soo-Yong Park Hyung Il Seo Ildoo Chung |
| author_facet | Seoeun Oh Soo-Yong Park Hyung Il Seo Ildoo Chung |
| author_sort | Seoeun Oh |
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| description | <b>Background and objectives:</b> The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; <b>Methods:</b> In this study, L-threonine polyurethane (LTPU) NPs have been fabricated by water-in-oil-in-water emulsion and solvent evaporation using biodegradable and biocompatible LTPU. This polymer was pre-synthesized through the use of an amino acid-based chain extender, desaminotyrosyl L-threonine hexyl ester (DLTHE), where urethane bonds are formed by poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer and 1,6-hexamethylene diisocyanate (HDI). LTPU is designed to be degraded by hydrolysis and enzymatic activity due to the presence of ester bonds and peptide bonds within the polymer backbone. LTPU NPs were fabricated by water-in-oil-in-water double emulsion solvent evaporation methods; <b>Results:</b> The polymerization of LTPU was confirmed by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and FT-IR spectroscopies. The molecular weights and polydispersity, determined with GPC, were 28,800 g/mol and 1.46, respectively. The morphology and size of NPs, characterized by DLS, FE-SEM, TEM, and confocal microscopy, showed smooth and spherical particles with diameters less than 200 nm; <b>Conclusions:</b> In addition, the drug loading, encapsulation efficiency, and drug release profiles, using UV-Vis spectroscopy, showed the highest encapsulation efficiency with 2.5% carboplatin and sustained release profile. |
| format | Article |
| id | doaj-art-40d0489eee6548759b429717bf357a48 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-40d0489eee6548759b429717bf357a482025-01-24T13:45:37ZengMDPI AGPharmaceutics1999-49232024-12-011712810.3390/pharmaceutics17010028L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin ReleaseSeoeun Oh0Soo-Yong Park1Hyung Il Seo2Ildoo Chung3Department of Polymer Science and Engineering, Pusan National University, Busan 46241, Republic of KoreaDepartment of Polymer Science and Engineering, Pusan National University, Busan 46241, Republic of KoreaDepartment of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, Republic of KoreaDepartment of Polymer Science and Engineering, Pusan National University, Busan 46241, Republic of Korea<b>Background and objectives:</b> The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; <b>Methods:</b> In this study, L-threonine polyurethane (LTPU) NPs have been fabricated by water-in-oil-in-water emulsion and solvent evaporation using biodegradable and biocompatible LTPU. This polymer was pre-synthesized through the use of an amino acid-based chain extender, desaminotyrosyl L-threonine hexyl ester (DLTHE), where urethane bonds are formed by poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer and 1,6-hexamethylene diisocyanate (HDI). LTPU is designed to be degraded by hydrolysis and enzymatic activity due to the presence of ester bonds and peptide bonds within the polymer backbone. LTPU NPs were fabricated by water-in-oil-in-water double emulsion solvent evaporation methods; <b>Results:</b> The polymerization of LTPU was confirmed by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and FT-IR spectroscopies. The molecular weights and polydispersity, determined with GPC, were 28,800 g/mol and 1.46, respectively. The morphology and size of NPs, characterized by DLS, FE-SEM, TEM, and confocal microscopy, showed smooth and spherical particles with diameters less than 200 nm; <b>Conclusions:</b> In addition, the drug loading, encapsulation efficiency, and drug release profiles, using UV-Vis spectroscopy, showed the highest encapsulation efficiency with 2.5% carboplatin and sustained release profile.https://www.mdpi.com/1999-4923/17/1/28biodegradabledouble emulsionnanoparticlescarboplatin |
| spellingShingle | Seoeun Oh Soo-Yong Park Hyung Il Seo Ildoo Chung L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release Pharmaceutics biodegradable double emulsion nanoparticles carboplatin |
| title | L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release |
| title_full | L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release |
| title_fullStr | L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release |
| title_full_unstemmed | L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release |
| title_short | L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release |
| title_sort | l threonine derived biodegradable polyurethane nanoparticles for sustained carboplatin release |
| topic | biodegradable double emulsion nanoparticles carboplatin |
| url | https://www.mdpi.com/1999-4923/17/1/28 |
| work_keys_str_mv | AT seoeunoh lthreoninederivedbiodegradablepolyurethanenanoparticlesforsustainedcarboplatinrelease AT sooyongpark lthreoninederivedbiodegradablepolyurethanenanoparticlesforsustainedcarboplatinrelease AT hyungilseo lthreoninederivedbiodegradablepolyurethanenanoparticlesforsustainedcarboplatinrelease AT ildoochung lthreoninederivedbiodegradablepolyurethanenanoparticlesforsustainedcarboplatinrelease |