In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review
Background: Burkholderia cepacia complex (BCC) is a group of multi-drug resistant (MDR) pathogens that are challenging to treat, especially in cystic fibrosis (CF) patients. Ceftazidime-avibactam is a promising antibiotic combination for treating BCC infections, but its efficacy requires further in...
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| Format: | Article |
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Elsevier
2025-08-01
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| Series: | New Microbes and New Infections |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S205229752500040X |
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| author | Abolfazl Rafati Zomorodi Leila Ghanbari_Afra Hossein Faridafshar Seyed Nooreddin Faraji Fatemeh Zarepour Maryamosadat Mavaei Mohammad Rahmanian |
| author_facet | Abolfazl Rafati Zomorodi Leila Ghanbari_Afra Hossein Faridafshar Seyed Nooreddin Faraji Fatemeh Zarepour Maryamosadat Mavaei Mohammad Rahmanian |
| author_sort | Abolfazl Rafati Zomorodi |
| collection | DOAJ |
| description | Background: Burkholderia cepacia complex (BCC) is a group of multi-drug resistant (MDR) pathogens that are challenging to treat, especially in cystic fibrosis (CF) patients. Ceftazidime-avibactam is a promising antibiotic combination for treating BCC infections, but its efficacy requires further in vitro evaluation. Methods: This systematic review was conducted following the PRISMA guidelines to assess the in vitro susceptibility of BCC strains to ceftazidime-avibactam. We systematically searched PubMed, Web of Science, Scopus, and Embase databases. Inclusion criteria required original articles reporting on BCC susceptibility to ceftazidime-avibactam using standard antimicrobial susceptibility testing methods. Results: A total of 9 studies met the inclusion criteria. These studies were conducted between 2010 and 2024, with data from the USA, France, Germany, Belgium, and other countries. The studies used various methods, including agar dilution, broth microdilution, and disc diffusion. The minimum inhibitory concentration (MIC) range for ceftazidime-avibactam was found to vary, with the combination showing significantly improved susceptibility compared to ceftazidime alone. Conclusion: This systematic review demonstrates that ceftazidime-avibactam significantly enhances the susceptibility of BCC strains, supporting its potential as an effective therapeutic option for BCC infections in CF patients. Further clinical studies are needed to confirm these findings and guide treatment strategies. |
| format | Article |
| id | doaj-art-40cdb4c61d214b75b51e50ef169562ed |
| institution | Kabale University |
| issn | 2052-2975 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj-art-40cdb4c61d214b75b51e50ef169562ed2025-08-20T03:38:48ZengElsevierNew Microbes and New Infections2052-29752025-08-016610160110.1016/j.nmni.2025.101601In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic reviewAbolfazl Rafati Zomorodi0Leila Ghanbari_Afra1Hossein Faridafshar2Seyed Nooreddin Faraji3Fatemeh Zarepour4Maryamosadat Mavaei5Mohammad Rahmanian6Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranInstructor, Department of Medical Surgical Nursing, Faculty of Nursing, Qom University of Medical Sciences, Qom, IranDepartment of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author. SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran.Background: Burkholderia cepacia complex (BCC) is a group of multi-drug resistant (MDR) pathogens that are challenging to treat, especially in cystic fibrosis (CF) patients. Ceftazidime-avibactam is a promising antibiotic combination for treating BCC infections, but its efficacy requires further in vitro evaluation. Methods: This systematic review was conducted following the PRISMA guidelines to assess the in vitro susceptibility of BCC strains to ceftazidime-avibactam. We systematically searched PubMed, Web of Science, Scopus, and Embase databases. Inclusion criteria required original articles reporting on BCC susceptibility to ceftazidime-avibactam using standard antimicrobial susceptibility testing methods. Results: A total of 9 studies met the inclusion criteria. These studies were conducted between 2010 and 2024, with data from the USA, France, Germany, Belgium, and other countries. The studies used various methods, including agar dilution, broth microdilution, and disc diffusion. The minimum inhibitory concentration (MIC) range for ceftazidime-avibactam was found to vary, with the combination showing significantly improved susceptibility compared to ceftazidime alone. Conclusion: This systematic review demonstrates that ceftazidime-avibactam significantly enhances the susceptibility of BCC strains, supporting its potential as an effective therapeutic option for BCC infections in CF patients. Further clinical studies are needed to confirm these findings and guide treatment strategies.http://www.sciencedirect.com/science/article/pii/S205229752500040XBurkholderia cepaciaCeftazidime/avibactamCystic fibrosisRespiratory tract infectionsSystematic review |
| spellingShingle | Abolfazl Rafati Zomorodi Leila Ghanbari_Afra Hossein Faridafshar Seyed Nooreddin Faraji Fatemeh Zarepour Maryamosadat Mavaei Mohammad Rahmanian In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review New Microbes and New Infections Burkholderia cepacia Ceftazidime/avibactam Cystic fibrosis Respiratory tract infections Systematic review |
| title | In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review |
| title_full | In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review |
| title_fullStr | In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review |
| title_full_unstemmed | In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review |
| title_short | In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review |
| title_sort | in vitro susceptibility of burkholderia cepacia to ceftazidime avibactam a systematic review |
| topic | Burkholderia cepacia Ceftazidime/avibactam Cystic fibrosis Respiratory tract infections Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S205229752500040X |
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